Famotidine, calcium carbonate, and magnesium hydroxide vs Misoprostol

Interacting Drugs
Famotidine, calcium carbonate, and magnesium hydroxide
vs
Misoprostol
Security Level
Moderate, Consider therapy modification
Mechanism
Misoprostol: Antacids may enhance the adverse/toxic effect of Misoprostol. More specifically, concomitant use with magnesium-containing antacids may increase the risk of diarrhea.
Management
Avoid concomitant use of misoprostol and magnesium-containing antacids. In patients requiring antacid therapy, employ magnesium-free preparations. Monitor for increased adverse effects (e.g., diarrhea, dehydration).

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