Ezetimibe and simvastatin vs Verapamil

Interacting Drugs
Ezetimibe and simvastatin
vs
Verapamil
Security Level
Moderate, Consider therapy modification
Mechanism
Verapamil: May increase the serum concentration of Simvastatin.
Management
Avoid concurrent use of verapamil with simvastatin when possible. If used together, limit adult maximum simvastatin dose to 10 mg/day, and avoid Simcor (simvastatin/niacin) because fixed simvastatin doses in the product exceed this maximum.

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