Ezetimibe and simvastatin vs Antifungal Agents (Azole Derivatives, Systemic)

Interacting Drugs
Ezetimibe and simvastatin
vs
Antifungal Agents (Azole Derivatives, Systemic)
Security Level
Moderate, Consider therapy modification
Mechanism
Antifungal Agents (Azole Derivatives, Systemic): May decrease the metabolism of HMG-CoA Reductase Inhibitors.
Management
Consider use of HMG-CoA reductase inhibitors posing the least rhabdomyolysis risk (e.g. fluva- or pravastatin), and monitor for signs/symptoms of rhabdomyolysis. Do not use keto- or itraconazole with lova- or simvastatin, or posaconazole with simvastatin.

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