Ezetimibe and simvastatin vs Amiodarone

Interacting Drugs
Ezetimibe and simvastatin
vs
Amiodarone
Security Level
Moderate, Consider therapy modification
Mechanism
Amiodarone: May decrease the metabolism of HMG-CoA Reductase Inhibitors.
Management
Dose of HMG-CoA reductase inhibitor may need to be reduced (e.g., simvastatin prescribing information recommends limiting adult maximum dose to 10 mg/day). Avoid Simcor (simvastatin/niacin) as fixed simvastatin doses exceed recommended maximum doses.

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