Ethinyl estradiol and ethynodiol diacetate vs Topiramate

Interacting Drugs
Ethinyl estradiol and ethynodiol diacetate
vs
Topiramate
Security Level
Moderate, Consider therapy modification
Mechanism
Topiramate: May decrease the serum concentration of Contraceptives (Progestins).
Management
Caution patients that this combination may be associated with reduced contraceptive effectiveness. Consider adding an additional (non-hormonal) contraceptive method.

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Ethinyl estradiol and ethynodiol diacetate vs Topiramate

Interacting Drugs
Ethinyl estradiol and ethynodiol diacetate
vs
Topiramate
Security Level
Moderate, Consider therapy modification
Mechanism
Topiramate: May decrease the serum concentration of Contraceptives (Estrogens). Contraceptive failure is possible.
Management
Risk appears greatest for higher topiramate doses (200 mg/day or greater). Some have recommended using at least 50 mcg/day of ethinyl estradiol, but the effectiveness of this is unclear. Consider a nonhormonal form of contraception.

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