Ethinyl estradiol and ethynodiol diacetate vs Tipranavir

Interacting Drugs
Ethinyl estradiol and ethynodiol diacetate
vs
Tipranavir
Security Level
Moderate, Consider therapy modification
Mechanism
Tipranavir: Estrogen Derivatives may enhance the dermatologic adverse effect of Tipranavir. The combination of tipranavir/ritonavir and ethinyl estradiol/norethindrone was associated with a high incidence of skin rash. Tipranavir may decrease the serum concentration of Estrogen Derivatives.
Management
Women using hormonal contraceptives should consider alternative, non-hormonal forms of contraception.

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