Estropipate vs Somatropin

Interacting Drugs
Estropipate
vs
Somatropin
Security Level
Moderate, Consider therapy modification
Mechanism
Somatropin: Estrogen Derivatives may diminish the therapeutic effect of Somatropin. Shown to be a concern with oral hormone replacement therapy in postmenopausal women.
Management
Monitor for reduced growth hormone efficacy. A larger somatropin dose may be required to reach treatment goal. This interaction does not appear to apply to non-orally administered estrogens (e.g., transdermal, vaginal ring).

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