Estradiol and norethindrone vs St Johns Wort

Interacting Drugs
Estradiol and norethindrone
vs
St Johns Wort
Security Level
Moderate, Consider therapy modification
Mechanism
St Johns Wort: May diminish the therapeutic effect of Contraceptives (Progestins). Contraceptive failure is possible.
Management
Consider using a product other than St John's wort. Contraceptive failure is possible. Use of an alternative, nonhormonal contraceptive is recommended.

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