Drospirenone and estradiol vs Sodium Phosphates

Interacting Drugs
Drospirenone and estradiol
vs
Sodium Phosphates
Security Level
Moderate, Consider therapy modification
Mechanism
Sodium Phosphates: Diuretics may enhance the nephrotoxic effect of Sodium Phosphates. Specifically, the risk of acute phosphate nephropathy may be enhanced.
Management
Consider avoiding this combination by temporarily suspending treatment with diuretics, or seeking alternatives to oral sodium phosphate bowel preparation. If the combination cannot be avoided, hydrate adequately and monitor fluid and renal status.

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