Drospirenone and estradiol vs Rifamycin Derivatives

Interacting Drugs
Drospirenone and estradiol
vs
Rifamycin Derivatives
Security Level
Moderate, Consider therapy modification
Mechanism
Rifamycin Derivatives: May decrease the serum concentration of Contraceptives (Progestins). Contraceptive failure is possible.
Management
Contraceptive failure is possible. Use of an alternative, nonhormonal contraceptive is recommended.

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