Diltiazem vs Simvastatin

Interacting Drugs
Diltiazem
vs
Simvastatin
Security Level
Moderate, Consider therapy modification
Mechanism
Simvastatin: May increase the serum concentration of Diltiazem. Diltiazem may increase the serum concentration of Simvastatin.
Management
Avoid concurrent use of diltiazem with simvastatin when possible. If used together, limit adult maximum simvastatin dose to 10 mg/day, and avoid Simcor (simvastatin/niacin) because fixed simvastatin doses in the product exceed this maximum.

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Other Interactions of Simvastatin

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