Diltiazem vs Fosphenytoin

Interacting Drugs
Diltiazem
vs
Fosphenytoin
Security Level
Moderate, Consider therapy modification
Mechanism
Fosphenytoin: Calcium Channel Blockers may increase the serum concentration of Fosphenytoin.
Management
Monitor for phenytoin toxicity with concomitant use of a calcium channel blocker (CCB) or decreased phenytoin effects with CCB discontinuation. Monitor for decreased CCB therapeutic effects. Nimodipine Canadian labeling contraindicates use with phenytoin.

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