Diltiazem vs Colchicine

Interacting Drugs
Diltiazem
vs
Colchicine
Security Level
Moderate, Consider therapy modification
Mechanism
Colchicine: CYP3A4 Inhibitors (Moderate) may increase the serum concentration of Colchicine.
Management
Reduce colchicine dose as directed when using with a moderate CYP3A4 inhibitor, and increase monitoring for colchicine-related toxicity. Use extra caution in patients with impaired renal and/or hepatic function.

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