Diltiazem vs Barbiturates

Interacting Drugs
Diltiazem
vs
Barbiturates
Security Level
Minor, Monitor Therapy
Mechanism
Barbiturates: May increase the metabolism of Calcium Channel Blockers.
Management
Monitor for decreased therapeutic effects of calcium channel blockers with concomitant barbiturate therapy. Calcium channel blocker dose adjustments may be necessary. Nimodipine Canadian labeling contraindicates concomitant use with phenobarbital.

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