Interacting Drugs |
Darunavir vs HMG-CoA Reductase Inhibitors |
Security Level |
|
Mechanism |
HMG-CoA Reductase Inhibitors: Protease Inhibitors may increase the serum concentration of HMG-CoA Reductase Inhibitors. Limited data suggest pravastatin may slightly decrease protease inhibitor concentrations. |
Management |
Lovastatin and simvastatin are contraindicated with protease inhibitors; also, avoid rosuvastatin with indinavir. Use lowest possible HMG-CoA reductase inhibitor dose and monitor for signs of toxicity if these agents are used concomitantly. Exceptions: Fluvastatin. |
Darunavir vs HMG-CoA Reductase Inhibitors
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Other Interactions of Darunavir
Other Interactions of HMG-CoA Reductase Inhibitors
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