Citric acid bladder mixture vs Bisphosphonate Derivatives

Interacting Drugs
Citric acid bladder mixture
vs
Bisphosphonate Derivatives
Security Level
Moderate, Consider therapy modification
Mechanism
Bisphosphonate Derivatives: Antacids may decrease the serum concentration of Bisphosphonate Derivatives.
Management
Avoid administration of antacids containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid.

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