Chlorothiazide vs Topiramate

Interacting Drugs
Chlorothiazide
vs
Topiramate
Security Level
Moderate, Consider therapy modification
Mechanism
Topiramate: Thiazide Diuretics may enhance the hypokalemic effect of Topiramate. Thiazide Diuretics may increase the serum concentration of Topiramate.
Management
Monitor for increased topiramate levels/adverse effects (e.g., hypokalemia) with initiation/dose increase of a thiazide diuretic. Closely monitor serum potassium concentrations with concomitant therapy. Topiramate dose reductions may be necessary.

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