Captopril and hydrochlorothiazide vs Antacids

Interacting Drugs
Captopril and hydrochlorothiazide
vs
Antacids
Security Level
Moderate, Consider therapy modification
Mechanism
Antacids: May decrease the serum concentration of ACE Inhibitors.
Management
Separate fosinopril administration from antacids by at least 2 hours. US and Canadian recommendations for use of other ACE- inhibitors with antacids may vary. Consult appropriate labeling. Monitor for decreased therapeutic effects of ACE-inhibitors.

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