Calcium polystyrene sulfonate vs Laxatives

Interacting Drugs
Calcium polystyrene sulfonate
vs
Laxatives
Security Level
Major, Avoid combination
Mechanism
Laxatives: May enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. More specifically, concomitant use of calcium polystyrene sulfonate with magnesium-containing laxatives may result in metabolic alkalosis or with sorbitol may result in intestinal necrosis.
Management
Avoid concomitant use of calcium polystyrene sulfonate (rectal or oral) and magnesium-containing laxatives or sorbitol. Exceptions: Bisacodyl; Dehydrocholic Acid; Lactulose; Polycarbophil; Psyllium.

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