Calcium carbonate and simethicone vs Eltrombopag

Interacting Drugs
Calcium carbonate and simethicone
vs
Eltrombopag
Security Level
Moderate, Consider therapy modification
Mechanism
Eltrombopag: Calcium Salts may decrease the serum concentration of Eltrombopag.
Management
Separate administration of eltrombopag and any polyvalent cation (e.g., calcium-containing products) by at least 4 hours.

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