Aluminum hydroxide, magnesium hydroxide, and simethicone vs Mesalamine

Interacting Drugs
Aluminum hydroxide, magnesium hydroxide, and simethicone
vs
Mesalamine
Security Level
Moderate, Consider therapy modification
Mechanism
Mesalamine: Antacids may diminish the therapeutic effect of Mesalamine. Antacid-mediated increases in gastrointestinal pH may cause the premature release of mesalamine from specific sustained-release mesalamine products.
Management
Avoid concurrent administration of antacids with sustained-release mesalamine products. Separating antacid and mesalamine administration, and/or using lower antacid doses may be adequate means of avoiding this interaction.

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