Aluminum hydroxide, magnesium hydroxide, and simethicone vs Calcium Polystyrene Sulfonate

Interacting Drugs
Aluminum hydroxide, magnesium hydroxide, and simethicone
vs
Calcium Polystyrene Sulfonate
Security Level
Moderate, Consider therapy modification
Mechanism
Calcium Polystyrene Sulfonate: May enhance the adverse/toxic effect of Aluminum Hydroxide. More specifically, concomitant use of these agents may increase the risk for intestinal obstruction.
Management
Monitor for signs/symptoms of intestinal obstruction with concomitant use of calcium polystyrene sulfonate and aluminum hydroxide. Adequate fluid intake, laxative use, alternative antacid agents, and/or limiting duration of therapy may help reduce risks.

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Other Interactions of Calcium Polystyrene Sulfonate

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Aluminum hydroxide, magnesium hydroxide, and simethicone vs Calcium Polystyrene Sulfonate

Interacting Drugs
Aluminum hydroxide, magnesium hydroxide, and simethicone
vs
Calcium Polystyrene Sulfonate
Security Level
Moderate, Consider therapy modification
Mechanism
Calcium Polystyrene Sulfonate: Antacids may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. The combined use of these two agents may result in metabolic alkalosis and/or loss of efficacy of the cation exchange resin.
Management
To minimize this interaction, consider: a)separating doses by 2 or more hours; b)rectal administration of the exchange resin; or c)alternatives to antacids. Monitor for metabolic alkalosis and attenuation of CPS effects. Avoid magnesium hydroxide.

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Other Interactions of Calcium Polystyrene Sulfonate

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Aluminum hydroxide, magnesium hydroxide, and simethicone vs Calcium Polystyrene Sulfonate

Interacting Drugs
Aluminum hydroxide, magnesium hydroxide, and simethicone
vs
Calcium Polystyrene Sulfonate
Security Level
Major, Avoid combination
Mechanism
Calcium Polystyrene Sulfonate: Laxatives may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. More specifically, concomitant use of calcium polystyrene sulfonate with magnesium-containing laxatives may result in metabolic alkalosis or with sorbitol may result in intestinal necrosis.
Management
Avoid concomitant use of calcium polystyrene sulfonate (rectal or oral) and magnesium-containing laxatives or sorbitol.

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Other Interactions of Calcium Polystyrene Sulfonate

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