Aliskiren and hydrochlorothiazide vs Grapefruit Juice

Interacting Drugs
Aliskiren and hydrochlorothiazide
vs
Grapefruit Juice
Security Level
Moderate, Consider therapy modification
Mechanism
Grapefruit Juice: May decrease the serum concentration of Aliskiren.
Management
Avoid concomitant use of aliskiren and grapefruit juice. Separation of aliskiren and grapefruit juice administration by several hours may reduce the chance for interaction. Monitor for decreased aliskiren levels/effects.

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