Acyclovir (systemic) vs Zoster Vaccine

Interacting Drugs
Acyclovir (systemic)
vs
Zoster Vaccine
Security Level
Major, Avoid combination
Mechanism
Zoster Vaccine: Acyclovir-Valacyclovir may diminish the therapeutic effect of Zoster Vaccine.
Management
When possible, discontinue antiviral agents with anti-zoster activity (i.e., acyclovir, valacyclovir, famciclovir) for at least 24 hours prior to and 14 days after receiving a live attenuated zoster vaccine.

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