Acetaminophen, dextromethorphan, and doxylamine vs Probenecid

Interacting Drugs
Acetaminophen, dextromethorphan, and doxylamine
vs
Probenecid
Security Level
Moderate, Consider therapy modification
Mechanism
Probenecid: May increase the serum concentration of Acetaminophen. Probenecid may also limit the formation of at least one major non-toxic metabolite, possibly increasing the potential for formation of the toxic NAPQI metabolite.
Management
Consider therapy modification

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