Acetaminophen, dextromethorphan, and doxylamine vs Metyrapone

Interacting Drugs
Acetaminophen, dextromethorphan, and doxylamine
vs
Metyrapone
Security Level
Minor, Monitor Therapy
Mechanism
Metyrapone: May increase the serum concentration of Acetaminophen. More importantly, by inhibiting the conjugative metabolism of acetaminophen, metyrapone may shift the metabolism towards the oxidative route that produces a hepatotoxic metabolite.
Management
Monitor therapy

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