Acetaminophen, dextromethorphan, and doxylamine vs Abiraterone Acetate

Interacting Drugs
Acetaminophen, dextromethorphan, and doxylamine
vs
Abiraterone Acetate
Security Level
Moderate, Consider therapy modification
Mechanism
Abiraterone Acetate: May increase the serum concentration of CYP2D6 Substrates.
Management
Avoid concurrent use of abiraterone with CYP2D6 substrates that have a narrow therapeutic index whenever possible. When concurrent use is not avoidable, monitor patients closely for signs/symptoms of toxicity.

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