Zinc

Indications
Oral
Zinc deficiency
Adult: 50 mg of elemental zinc tid.
Intravenous
Zinc deficiency
Adult: 6.5 mg elemental zinc (100 micromoles) daily.
Ophthalmic
Minor eye irritation
Adult: In combination with a vasoconstrictor, 1-2 drops are instilled into the eye 2-4 times daily.

Incompatibility: Mixing sodium borate, glycerin and methylcellulose with zinc sulfate may cause preciptation.
Warnings / Precautions
Oral/IV: Monitor CBC and serum cholesterol to detect early signs of copper deficiency, especially if prolonged high dose use of zinc. Topical: Consult medical advice if relief not seen within 3 days.
Adverse Reactions
Abdominal pain, dyspepsia, nausea, vomiting, diarrhoea, gastric irritation, gastritis. Prolonged use may cause copper deficiency (e.g. sideroblastic anaemia, neutropenia)
Drug Interactions
Reduced absorption of both zinc and oral iron supplements, penicillamine and tetracyclines when admin concomitantly. Phosphorus-containing preparations reduce zinc absorption. Zn sulfate reduces absorption of copper and flouroquinolones e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin. Reduced zinc absorption with calcium co-admin. Reduced bisphosphonates absorption with concurrent zinc admin.
See Below for More zinc sulfate Drug Interactions
Food Interactions
Absorption of Zn sulfate is reduced by milk, phytates (present in cereals, rice, corn, legumes) and some minerals (e.g. iron, calcium).
Mechanism of Actions
As an ophthalmic preparation, zinc sulfate precipitates protein and this is responsible for the astringent and weak antiseptic activity of Zn sulfate. It also produces mild vasodilation. Zinc sulfate can also be used orally or systemically as a zinc supplement. 220 mg of zinc sulfate (heptahydrate) contains 50 mg of elemental zinc.
Absorption: Following oral administration, 20-30% of dietary Zn is absorbed.
Distribution: Widely distributed but concentrated within the muscle, bone, skin and prostatic fluids.
Excretion: Primarily via faeces at approx 90%; small amounts via urine at approx 2% and via perspiration.
Storage Conditions
Ophthalmic: Store below 40°C.
ATC Classification
A12CB01 - zinc sulfate ; Belongs to the class of zinc-containing preparations. Used as dietary supplements.
Storage
Ophthalmic: Store below 40°C.
Available As
  • Zinc –
  • Zinc 0.0004% w/v
  • Zinc 0.15 mg
  • Zinc 0.2% w/w
  • Zinc 0.25 mg
  • Zinc 0.5 mg
  • Zinc 0.50% w/w
  • Zinc 0.7 mg
  • Zinc 0.9 mg
  • Zinc 1 mg
  • Zinc 1.11 mg
  • Zinc 1.2 mg
  • Zinc 1.25 mg
  • Zinc 1.5 mg
  • Zinc 1.6 mg
  • Zinc 1.88 mg
  • Zinc 10 mg
  • Zinc 11 mcg
  • Zinc 11 mg
  • Zinc 11.11 mg
  • Zinc 11.25 mg
  • Zinc 11.5 mg
  • Zinc 115 mcg
  • Zinc 12 mg
  • Zinc 12.5 mg
  • Zinc 13.3 mg
  • Zinc 14 mg
  • Zinc 15 gm
  • Zinc 15 mg
  • Zinc 16 mg
  • Zinc 16.2 mg
  • Zinc 16.8 mcg
  • Zinc 16.8 mg
  • Zinc 17.6 mg
  • Zinc 18.8 mg
  • Zinc 19 mg
  • Zinc 2 mg
  • Zinc 2.1 mg
  • Zinc 2.2 mg
  • Zinc 2.3 mg
  • Zinc 2.4 mg
  • Zinc 2.5 mg
  • Zinc 2.50% w/w
  • Zinc 2.73 mg
  • Zinc 2.75 mg
  • Zinc 20 mg
  • Zinc 20.61 mg
  • Zinc 22 mg
  • Zinc 22.2 mg
  • Zinc 22.5 mg
  • Zinc 25 mg
  • Zinc 27.4 mg
  • Zinc 27.45 mg
  • Zinc 27.5 mg
  • Zinc 27.50 mg
  • Zinc 27.54 mg
  • Zinc 3 mg
  • Zinc 3.0 mg
  • Zinc 3.1 mg
  • Zinc 3.10 mg
  • Zinc 3.34 mg
  • Zinc 3.5 mg
  • Zinc 3.9 mg
  • Zinc 30 mcg
  • Zinc 30 mg
  • Zinc 32.5 mg
  • Zinc 33 mg
  • Zinc 35 mg
  • Zinc 4 mg
  • Zinc 4.3 mg
  • Zinc 4.48 mg
  • Zinc 4.5 mg
  • Zinc 4.71 mg
  • Zinc 40 mg
  • Zinc 41.2 mg
  • Zinc 41.4 mg
  • Zinc 41.7 mg
  • Zinc 44 mg
  • Zinc 44.4 mg
  • Zinc 45 mg
  • Zinc 46 mg
  • Zinc 4800 mcg
  • Zinc 5 mg
  • Zinc 5%
  • Zinc 5% w/v
  • Zinc 5.5 mg
  • Zinc 5.6 mg
  • Zinc 5.63 mg
  • Zinc 5.7 mg
  • Zinc 50 mg
  • Zinc 53 mg
  • Zinc 54.93 mg
  • Zinc 55 mg
  • Zinc 57 mg
  • Zinc 57.5 mg
  • Zinc 5mg
  • Zinc 6.1 mg
  • Zinc 6.3 mg
  • Zinc 6.7 mg
  • Zinc 60 mg
  • Zinc 600 mcg
  • Zinc 61 mg
  • Zinc 61.5 mg
  • Zinc 61.8 mg
  • Zinc 68.5 mg
  • Zinc 7 mg
  • Zinc 7.25 mg
  • Zinc 7.5 mg
  • Zinc 7.50 mg
  • Zinc 7.55 mg
  • Zinc 75 mg
  • Zinc 8 mg
  • Zinc 80 mg
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