Vit K

Indications
Oral
Vitamin K deficiency due to drugs or malabsorption
Adult: 10-40 mg daily.
Oral
Over-anticoagulation
Adult: Up to 5 mg may be used. Dose depends on INR and degree of haemorrhage.
Intramuscular
Prophylaxis of vitamin K deficiency bleeding in neonates
Child: Neonate: 0.5-1 mg, given as a single dose via IM inj. Alternatively, 2 mg may be given orally, followed by a 2nd dose of 2 mg after 4-7 days.
Intravenous
Over-anticoagulation
Adult: 0.5-5 mg via slow IV inj. Dose depends on INR and degree of haemorrhage.
Parenteral
Vitamin K deficiency bleeding in neonates
Child: Infant: 1 mg by IV/IM/SC inj, further doses may be given if necessary
Contraindications
Hypersensitivity.
Warnings / Precautions
Increased risk of severe haemolytic anaemia in neonates after large doses; severe hepatic impairment; pregnancy. Premature neonates weighing <2.5 kg.
Adverse Reactions
Anaphylaxis, dyspnoea, cyanosis, pain, swelling, phloebitis at the Inj site, diaphoresis, dizziness, hypotension (rare), allergic reactions after SC and IM inj.
Drug Interactions
Decreased effect of oral anticoagulants.
See Below for More phytomenadione Drug Interactions
Mechanism of Actions
Phytomenadione promotes hepatic synthesis of clotting factors. It is a naturally occurring compound that is used to prevent and treat haemorrhages related to vitamin K deficiency.
Absorption: Requires bile for absorption in GI tract.
Distribution: Mainly in the liver.
Metabolism: Rapidly metabolised to glucuronide and sulfate conjugates.
Excretion: In bile and urine as metabolites.
Administration
May be taken with or without food.
Storage Conditions
Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Store at 15-30°C.
ATC Classification
B02BA01 - phytomenadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.
Storage
Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Store at 15-30°C.
Available As
  • Vit K 0.1 gm
  • Vit K 0.1 mg
  • Vit K 0.13 mg
  • Vit K 0.2%
  • Vit K 0.2% v/v
  • Vit K 0.2% w/w
  • Vit K 1 mg
  • Vit K 1.1 mg
  • Vit K 10 mcg
  • Vit K1 10 mcg
  • Vit K 10 mg
  • Vit K3 10 mg
  • Vit K 100 mcg
  • Vit K 100 mg
  • Vit K 106.7 mcg
  • Vit K 13 mcg
  • Vit K 150 mcg
  • Vit K 16 mcg
  • Vit K 18 mcg
  • Vit K 18.4 mcg
  • Vit K 19 mcg
  • Vit K 2.5 mcg
  • Vit K 20 mcg
  • Vit K3 20 mg
  • Vit K 200 mcg
  • Vit K 21.79 mcg
  • Vit K 21.8 mcg
  • Vit K 210 mcg
  • Vit K 25 mcg
  • Vit K 27.4 mcg
  • Vit K 27.5 mcg
  • Vit K 27.7 mcg
  • Vit K 28.3 mcg
  • Vit K 3.8 mcg
  • Vit K 30 mcg
  • Vit K 36 mcg
  • Vit K 38 mcg
  • Vit K 4 mcg
  • Vit K 40 mcg
  • Vit K 40 mg
  • Vit K 42 mcg
  • Vit K 45 mcg
  • Vit K 46.66 mcg
  • Vit K 48 mcg
  • Vit K 5 mcg
  • Vit K3 50 mcg
  • Vit K 50 mcg
  • Vit K 50 mg
  • Vit K 52 mcg
  • Vit K1 52 mcg
  • Vit K 570 mg
  • Vit K 65 mcg
  • Vit K 66.7 mcg
  • Vit K 7.2 mcg
  • Vit K3 70 mcg
  • Vit K1 70 mcg
  • Vit K 70 mcg
  • Vit K 78 mcg
  • Vit K 80 iu
  • Vit K3 80 mcg
  • Vit K 80 mcg
  • Vit K 9 mcg
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