Indications |
Oral Vitamin K deficiency due to drugs or malabsorption Adult: 10-40 mg daily. Oral Over-anticoagulation Adult: Up to 5 mg may be used. Dose depends on INR and degree of haemorrhage. Intramuscular Prophylaxis of vitamin K deficiency bleeding in neonates Child: Neonate: 0.5-1 mg, given as a single dose via IM inj. Alternatively, 2 mg may be given orally, followed by a 2nd dose of 2 mg after 4-7 days. Intravenous Over-anticoagulation Adult: 0.5-5 mg via slow IV inj. Dose depends on INR and degree of haemorrhage. Parenteral Vitamin K deficiency bleeding in neonates Child: Infant: 1 mg by IV/IM/SC inj, further doses may be given if necessary |
Contraindications |
Hypersensitivity. |
Warnings / Precautions |
Increased risk of severe haemolytic anaemia in neonates after large doses; severe hepatic impairment; pregnancy. Premature neonates weighing <2.5 kg. |
Adverse Reactions |
Anaphylaxis, dyspnoea, cyanosis, pain, swelling, phloebitis at the Inj site, diaphoresis, dizziness, hypotension (rare), allergic reactions after SC and IM inj. |
Drug Interactions |
Decreased effect of oral anticoagulants. See Below for More phytomenadione Drug Interactions |
Mechanism of Actions |
Phytomenadione promotes hepatic synthesis of clotting factors. It is a naturally occurring compound that is used to prevent and treat haemorrhages related to vitamin K deficiency. Absorption: Requires bile for absorption in GI tract. Distribution: Mainly in the liver. Metabolism: Rapidly metabolised to glucuronide and sulfate conjugates. Excretion: In bile and urine as metabolites. |
Administration |
May be taken with or without food. |
Storage Conditions |
Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Store at 15-30°C. |
ATC Classification |
B02BA01 - phytomenadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage. |
Storage |
Intramuscular: Store at 15-30°C. Intravenous: Store at 15-30°C. Oral: Store at 15-30°C. Parenteral: Store at 15-30°C. |
Available As |
|
Vit K
Post Review about Vit K Click here to cancel reply.
Vit K Containing Brands
Vit K is used in following diseases
Drug - Drug Interactions of Vit K
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.