Vit D

Therapeutic Class
anti-osteoporotic
Indications

Oral
Nutritional deficiency
Adult: 10 mcg (400 units) daily. May also be given via IM inj. 
Oral
Deficiency due to malabsorption states or liver diseases
Adult: Up to 1 mg (40 000 units) daily. May also be given via IM inj. 
Oral
Hypocalcaemia caused by hypoparathyroidism
Adult: Up to 5 mg (200 000 units) daily. May also be given via IM inj.

Contraindications

Hypercalcaemia. Evidence of vitamin D toxicity.

Warnings / Precautions

Excessive intake may lead to development of hyperphosphataemia or hypercalcaemia. Infants, renal impairment or calculi, heart disease. Monitor plasma phosphate & calcium level. Pregnancy, lactation.

Adverse Reactions

Hyperphosphataemia or hypercalcaemia (in excessive intake). Associated effects of hypercalcaemia include hypercalciuria, ectopic calcification, & renal & CV damage.

Drug Interactions

Increased risk of hypercalcaemia if given with thiazide diuretics, calcium or phosphate. Antiepileptics (e.g. carbamazepine, phenobarbitone, phenytoin & primidone) may increase vitamin D requirements. Rifampicin & isoniazid may reduce efficacy of vitamin D. Corticosteroids may counteract the effect of vitamin D. Digoxin or any cardiac glycoside. Reduced absorption when taken with cholestyramine, colestipol, mineral oil, orlistat. Ketoconazole.

Lab Interactions

Interfere with Zlatkis-Zak reaction causing a falsely increased serum cholesterol determination.

Food Interactions

Olestra (fat substitute).

Mechanism of Actions

Vit D may have anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant & mood-modulatory activities. Along with parathyroid hormone & calcitonin, regulate serum calcium conc.
Onset: Slow.
Duration: Relatively prolonged duration of action.
Absorption: Well absorbed from the GI tract. Presence of bile is essential for adequate intestinal absorption. Hence absorption may be decreased in patients with decreased fat absorption.
Distribution: Bound to a specific α-globulin. Can be stored in adipose & muscle tissue for long periods of time. Slowly released from storage sites & skin where it is formed in the presence of sunlight or uv light. May distribute into breast milk.
Metabolism: Hydroxylated in the liver by the enzyme vitamin D 25-hydroxylase to form 25-hydroxycholecalciferol (calcifediol). Further hydroxylated in the kidneys by the enzyme vitamin D1-hydroxylase to form the active metabolites 1,25-dihydroxycholecalciferol (calcitriol). Further metabolism also occurs in the kidneys, including the formation of the 1,24,25-trihydroxy derivatives.
Excretion: Mainly in the bile & faeces with only small amounts appearing in urine.

Administration

May be taken with or without food.

Pregnancy Category

A: Drug Pregnancy Category Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters

ATC Classification
A11CC05
Available As
  • Vit D2 0.08 mcg
  • Vit D6 0.20 mg
  • Vit D 0.25 mcg
  • Vit D3 0.25 mcg
  • Vit D3 0.51 mcg
  • Vit D 1.1 mcg
  • Vit D3 10 iu
  • Vit D 10 mcg
  • Vit D3 10 mg
  • Vit D 100 iu
  • Vit D3 100 iu
  • Vit D3 1000 iu
  • Vit D2 1000 iu
  • Vit D 1000 iu
  • Vit D 12.9 iu
  • Vit D3 1200 iu
  • Vit D3 125 iu
  • Vit D3 125 mg
  • Vit D3 1250 iu
  • Vit D 126 iu
  • Vit D3 133 iu
  • Vit D3 135 iu
  • Vit D3 15 iu
  • Vit D 150 iu
  • Vit D3 150 iu
  • Vit D3 160 iu
  • Vit D3 168 iu
  • Vit D3 175 iu
  • Vit D 176 iu
  • Vit D 185 iu
  • Vit D 2.3 mcg
  • Vit D 2.4 mcg
  • Vit D3 2.5 iu
  • Vit D 2.7 mcg
  • Vit D 2.8 mcg
  • Vit D3 200 i.u
  • Vit D2 200 iu
  • Vit D3 200 iu
  • Vit D 200 iu
  • Vit D3 200 mg
  • Vit D3 2000 i.u
  • Vit D3 2000 iu
  • Vit D3 208.3 iu
  • Vit D 2083 iu
  • Vit D 21.8 iu
  • Vit D 220 iu
  • Vit D3 225 iu
  • Vit D3 25 iu
  • Vit D3 25 mg
  • Vit D2 250 iu
  • Vit D3 250 iu
  • Vit D 250 iu
  • Vit D3 250 mg
  • Vit D3 270 iu
  • Vit D 3.9 mcg
  • Vit D3 30 iu
  • Vit D3 30 mg
  • Vit D 300 iu
  • Vit D2 300 iu
  • Vit D3 300 iu
  • Vit D3 300000 iu
  • Vit D 315 iu
  • Vit D3 320 iu
  • Vit D3 3200 iu
  • Vit D 3200 iu
  • Vit D 324 iu
  • Vit D 330 iu
  • Vit D3 333 iu
  • Vit D 3333 iu
  • Vit D 345 iu
  • Vit D3 35 iu
  • Vit D 360 iu
  • Vit D 4 mcg
  • Vit D3 4 mcg
  • Vit D3 4.2 mcg
  • Vit D 4.2 mcg
  • Vit D 4.4 mcg
  • Vit D 4.63 mcg
  • Vit D 40 iu
  • Vit D3 40 mg
  • Vit D 40.5 iu
  • Vit D3 400 iu
  • Vit D 400 iu
  • Vit D2 400 iu
  • Vit D3 400 mg
  • Vit D 42 iu
  • Vit D3 420 iu
  • Vit D 430 iu
  • Vit D 44 iu
  • Vit D3 450 iu
  • Vit D3 5 iu
  • Vit D 5 mcg
  • Vit D3 5 mcg
  • Vit D3 5 mg
  • Vit D 5 mg
  • Vit D 5.3 mcg
  • Vit D 5.6 mcg
  • Vit D3 50 iu
  • Vit D 50 iu
  • Vit D 50 mcg
  • Vit D 50 mg
  • Vit D3 500 iu
  • Vit D 500 iu
  • Vit D3 500 mg
  • Vit D3 5000 iu
  • Vit D 502 iu
  • Vit D 520 iu
  • Vit D 533.3 iu
  • Vit D 54 iu
  • Vit D 550 iu
  • Vit D 6 mcg
  • Vit D3 60,000 iu
  • Vit D 600 iu
  • Vit D3 600 iu
  • Vit D3 6000 iu
  • Vit D3 60000 iu
  • Vit D3 600000 iu
  • Vit D3 62.5 iu
  • Vit D3 630 iu
  • Vit D3 666 iu
  • Vit D 667 iu
  • Vit D 7 mcg
  • Vit D 70 mcg
  • Vit D 700 iu
  • Vit D 72 iu
  • Vit D 8 mcg
  • Vit D3 8 mg
  • Vit D 8.3 mcg
  • Vit D 800 iu
  • Vit D3 800 iu
  • Vit D3 83 mg
  • Vit D 833 iu
  • Vit D 86 iu
  • Vit D 9 mcg
  • Vit D3 900 iu
  • Vit D 94 iu
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    Vit D Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Becadex Glaxo Smithkline Pharmaceuticals Ltd. 1 Tablet
    ₹ 0.21
    500 Tablet
    ₹ 104.43
  • More Information Vit B1 2 mg
  • More Information Vit A 2500 iu
  • More Information Vit D 200 iu
  • More Information Vit C 30 mg
  • More Information Vit B2 2 mg
  • More Information Vit B3 25 mg
  • More Information Diabasic Calcium Phosphate 250 mg
  • See Brands having above combination
    Drop Becadex (15 ml) Glaxo Smithkline Pharmaceuticals Ltd. 1 ml
    ₹ 0.67
    15 ml
    ₹ 10.04
  • More Information Vit B5 5 mg
  • More Information Vit D 667 iu
  • More Information Vit B6 2.5 mg
  • More Information Vit B1 3.3 mg
  • More Information Vit B2 1.7 mg
  • More Information Vit A 8300 iu
  • More Information Vit C 84 mg
  • More Information Vit B3 17 mg
  • See Brands having above combination
    Syrup Calorex D (200 ml) Iscon Lifesciences 1 ml
    ₹ 0.23
    200 ml
    ₹ 45.00
  • More Information Vit D3 200 iu
  • More Information Magnesium Hydroxide (Milk of Magnesia) 25 mg
  • More Information Calcium Carbonate 150 mg
  • More Information Zinc Gluconate 1.5 mg
  • See Brands having above combination
    Drop Dropovit (15 ml) Wyeth Pharmaceuticals Limited 0.6 ml
    ₹ 0.27
    15 ml
    ₹ 6.87
  • More Information Vit C 40 mg
  • More Information Vit E 5 iu
  • More Information Vit D 400 iu
  • More Information L-Lysine 60 mg
  • More Information Vit B1 1.2 mg
  • More Information Vit B2 1.2 mg
  • More Information Vit B5 3 mg
  • More Information Vit B3 15 mg
  • More Information Vit A 4800 iu
  • More Information Vit B6 1.2 mg
  • See Brands having above combination
    Capsule Filibon Wyeth Pharmaceuticals Limited 1 Capsule
    ₹ 0.86
    50 Capsule
    ₹ 43.12
  • More Information Vit B1 5 mg
  • More Information Vit B2 10 mg
  • More Information Niacinamide 50 mg
  • More Information Folic Acid (Vit B9) 1 mg
  • More Information Vit B6 2 mg
  • More Information Vit B12 500 mcg
  • More Information Ferrous Fumarate 90 mg
  • More Information Calcium Carbonate 130 mg
  • More Information Potassium 0.5 mg
  • More Information Vit A 7500 iu
  • More Information Potassium Sulphate 1.86 mg
  • More Information Zinc Oxide 0.1 mg
  • More Information Vit D 600 iu
  • More Information Cupric Oxide 0.18 mg
  • More Information Magnesium Oxide 0.25 mg
  • More Information Sodium Molybdate 0.06 mg
  • More Information Calcium Fluoride 0.03 mg
  • More Information Manganese Oxide 0.08 mg
  • More Information Calcium Ascorbate 100 mg
  • More Information Potassium Iodine 0.013 mg
  • See Brands having above combination
    Tablet Hexavit Indian Drugs & Pharmaceuticals Ltd. 1 Tablet
    ₹ 0.31
    10 Tablet
    ₹ 3.13
  • More Information Vit B1 2 mg
  • More Information Vit A 2500 iu
  • More Information Vit D 200 iu
  • More Information Vit B2 3 mg
  • More Information Vit C 50 mg
  • More Information Vit B3 20 mg
  • See Brands having above combination
    Syrup Indical (200 ml) Indi Pharma Pvt Ltd 5 ml
    ₹ 0.95
    200 ml
    ₹ 38.00
  • More Information Vit D 200 iu
  • More Information Calcium 150 mg
  • More Information Zinc 1.6 mg
  • More Information Magnesium Hydrochloride 25 mg
  • See Brands having above combination
    Tablet Manadol Wyeth Ltd. 1 Tablet
    ₹ 0.17
    25 Tablet
    ₹ 4.33
  • More Information Vit B1 5 mg
  • More Information Vit C 75 mg
  • More Information Nicotinamide 15 mg
  • More Information Vit A 5000 iu
  • More Information Vit B2 3 mg
  • More Information Vit B12 3 mcg
  • More Information Vit D 500 iu
  • More Information Ferrous Fumarate 75 mg
  • More Information Vit E 6 mg
  • More Information Vit B3 1 mg
  • See Brands having above combination
    Tablet Multivitamin (Smith) Smith Stanistreet Pharmaceuticals Ltd. 1 Tablet
    ₹ 0.10
    1000 Table
    ₹ 98.00
  • More Information Vit B1 1 mg
  • More Information Riboflavin 1 mg
  • More Information Vit A 1000 iu
  • More Information Vit D 100 iu
  • More Information Vit C 15 mg
  • See Brands having above combination
    Tablet Obzocalcium D (500 mg+500 iu) Healthy Life Pharma Pvt. Ltd. 1 Tablet
    ₹ 0.13
    500 Tablet
    ₹ 65.00
  • More Information Vit D3 500 iu
  • More Information Di-Calcium Phosphate 500 mg
  • See Brands having above combination
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    Vit D is used in following diseases

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    Drug - Drug Interactions of Vit D
    Interaction
    Minor, Monitor Therapy Magnesium carbonate, calcium carbonate, and folic acid vs Vitamin D Analogs
    Minor, Monitor Therapy Chlorothiazide vs Vitamin D Analogs
    Minor, Monitor Therapy Calcium chloride vs Vitamin D Analogs
    Major, Avoid combination Paricalcitol vs Vitamin D Analogs
    Minor, Monitor Therapy Aliskiren and hydrochlorothiazide vs Vitamin D Analogs
    Minor, Monitor Therapy Calcium acetate vs Vitamin D Analogs
    Major, Avoid combination Aluminum hydroxide, magnesium hydroxide, and simethicone vs Vitamin D Analogs
    Minor, Monitor Therapy Nadolol and bendroflumethiazide vs Vitamin D Analogs
    Minor, Monitor Therapy Atenolol and chlorthalidone vs Vitamin D Analogs
    Minor, Monitor Therapy Calcium and vitamin D vs Vitamin D Analogs
    Pages: 1 2 3 4 5 6 7 8 ... 11 12 13 Next