Vidagliptin

Indications	Oral Type 2 diabetes mellitus *Adult:* 50 mg bid when used with metformin or a thiazolidinedione or 50 mg once daily in the morning when used with a sulfonylurea. Not recommended to use >100 mg/day.
Warnings / Precautions	Renal impairment.
Adverse Reactions	Hypoglycaemia, delayed gastric emptying, nausea and vomiting. Flu-like symptoms, headache and dizziness may occur. Potentially Fatal: Stevens-Johnson syndrome.
Drug Interactions	Increased risk of hypoglycaemia when used with other anti-diabetic agents thus dose adjustments may be required. See Below for More vildagliptin Drug Interactions
Mechanism of Actions	Vildagliptin is a dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycaemic control by preventing DPP-4 from inactivating the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus prolonging incretin activity in response to ingestion of nutrients. This increases insulin sensitivity, decreases glucagon secretion and improves β-cell function. Absorption: Rapidly absorbed. Max plasma concentrations achieved 1-2 hr after oral admin. Oral bioavailability: About 85%. Metabolism: Metabolised by hydrolysis. Excretion: Mainly excreted in the urine.
Administration	May be taken with or without food.
ATC Classification	A10BH02 - vildagliptin ; Belongs to the class of dipeptidyl peptidase 4 (DPP-4) inhibitors. Used in the treatment of diabetes.
Available As	Vidagliptin 50 mg

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