Indications |
Oral Adjunct in treatment-resistant depression Adult: As L-tryptophan: 1 g tid. Max: 6 g daily. Elderly: Dose reduction may be needed. Renal impairment: Dose reduction may be needed. Hepatic impairment: Dose reduction may be needed. |
Contraindications |
History of eosinophilia-myalgia syndrome associated with tryptophan treatment. |
Warnings / Precautions |
May affect ability to drive or operate machinery. Monitor for suicidal thoughts or clinical worsening of depression during initial treatment period. Renal or hepatic impairment. Elderly. |
Adverse Reactions |
Nausea (take after food to minimise nausea), headache, lightheadedness, drowsiness, eosinophilia-myalgia syndrome. |
Overdose Reactions |
Symptoms: Drowsiness and vomiting. Management: Treatment is supportive. |
Drug Interactions |
Increased risk of serotonin syndrome with SSRI. Possible decrease in levodopa plasma levels with tryptophan. Potentially Fatal: Increased risk of severe behavioural and neurological toxicity with MAOI, start with lower initial dose of tryptophan if needed. See Below for More tryptophan Drug Interactions |
Mechanism of Actions |
Tryptophan is an essential amino acid which is the precursor of serotonin. It may be used as an adjunctive therapy in treatment-resistant depression. It is sometimes administered with pyridoxine and ascorbic acid. Due to its association with eosinophilia-myalgia syndrome, the use of tryptophan as dietary supplements (e.g. for insomnia) is limited or restricted. Absorption: Readily absorbed from GI tract. Distribution: Protein binding: Extensive, to plasma albumin. Metabolism: By liver to metabolites e.g. hydroxytryptophan and kynurenine derivatives. Excretion: Elimination half life (oral or IV L-tryptophan): 1-3 hr. |
ATC Classification |
N06AX02 - tryptophan ; Belongs to the class of other antidepressants. |
Available As |
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Tryptophan
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Tryptophan Containing Brands
Tryptophan is used in following diseases
Drug - Drug Interactions of Tryptophan
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