Trimetazidine

Indications
Oral
Angina pectoris, Meniere's disease
Adult: As conventional tab: 40-60 mg daily in divided doses.
Contraindications
Hypersensitivity. Pregnancy and lactation.
Adverse Reactions
GI disturbances, vomiting, nausea.
Mechanism of Actions
Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.
Absorption: Rapidly absorbed. Peak plasma concentration: within 2 hr (conventional tab); 5 hr (modified release).
Excretion: Via urine, mainly as unchanged drug. Half life: 6 hr (conventional); 7 hr (modified release).
Administration
Should be taken with food.
Storage Conditions
Oral: Store below 30°C.
ATC Classification
C01EB15 - trimetazidine ; Belongs to the class of other cardiac preparations.
Storage
Oral: Store below 30°C.
Available As
  • Trimetazidine 20 mg
  • Trimetazidine 35 mg
  • Trimetazidine 40 mg
  • Trimetazidine 60 mg
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