Terlipressin

Indications	Intravenous Acute oesophageal variceal haemorrhage *Adult:* Initially, 2 mg followed by 1 or 2 mg every 4-6 hr until bleeding is controlled, for up to 72 hr.
Contraindications	Hypersensitivity, vascular disease esp coronary artery disease, chronic nephritis (until normal blood-nitrogen conc attained). Pregnancy.
Warnings / Precautions	Patients with hypertension, artherosclerosis, cardiac disorders, conditions which may be aggravated by water retention, eg. heart failure.
Adverse Reactions	Abdominal cramps, cardiac arrhythmias, headache, transient blanching, increased arterial pressure. Potentially Fatal: MI, cardiac failure.
Mechanism of Actions	Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is a inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin are released following the enzymatic cleavage of 3 glycyl moieties. Duration: 4-6 hr.
Storage Conditions	Intravenous: Store below 25°C.
ATC Classification	H01BA04 - terlipressin ; Belongs to the class of vasopressin and analogues. Used in posterior pituitary lobe hormone preparations.
Storage	Intravenous: Store below 25°C.
Available As	Terlipressin 0.10 mg Terlipressin 1 mg

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