Terazosin

Indications
 Oral
Hypertension
Adult: Initially, 1 mg at bedtime, gradually increased at 7-day intervals according to patient's response. Maintenance: 2-10 mg once daily. Max: 20 mg/day in 1 or 2 divided doses.
Max Dosage: 20 mg daily in a single or 2 divided doses.
Oral
Benign prostatic hyperplasia
Adult: 1 mg at bedtime gradually increased at 7-day intervals according to patient's response. Maintenance: 5-10 mg once daily. Max: 20mg daily.
Contraindications
 Hypersensitivity to quinazoline derivatives.
Warnings / Precautions
 Elderly. Syncope and orthostatic associated with first dose phenomenon. Pregnancy and lactation.
Adverse Reactions
 Orthostatic hypotension, syncope, dizziness, fatigue, somnolence, peripheral oedema, headache, nasal congestion, nausea, blurred vision, postural hypotension, palpitations, priapism.
Drug Interactions
 Decreased antihypertensive effect with NSAIDs. Orthostatic hypotension potentiated by other antihypertensive agents.
See Below for More terazosin Drug Interactions
Mechanism of Actions
 Terazosin is an α1-adrenoceptor antagonist with a longer duration of action than prazosin. It blocks peripheral postsynaptic receptors resulting to decreased arterial tone. It relaxes smooth muscle of the bladder neck causing a reduction of bladder outlet obstruction. It reduces BP with minimal effect on heart rate. In the prostate, terazosin reduces the vascular tone which is the dynamic component in benign prostatic enlargement. Terazosin can increase urinary flow rates in patients with benign prostatic hyperplasia (BPH).
Onset: 15 min.
Duration: 24 hr.
Absorption: Rapid and almost complete from the GI tract; bioavailability 90%; peak plasma concentrations after 1 hr (oral).
Distribution: Protein-binding: 90-94%
Metabolism: Hepatic.
Excretion: Faeces and urine (as unchanged drug and metabolites); 12 hr (elimination half-life).
Administration
 May be taken with or without food.
ATC Classification
 G04CA03 - terazosin ; Belongs to the class of alpha-adrenoreceptor antagonists. Used in the treatment of benign prostatic hypertrophy.
Available As
  • Terazosin 1 mg
  • Terazosin 2 mg
  • Terazosin 3 mg
  • Terazosin 5 mg

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