Sulbactam

Indications
Intravenous
Gynaecological infections
Adult: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) every 6 hr. Max: 4 g sulbactam/day.
Child: ≥1 yr: 300 mg/kg daily (200 mg ampicillin/100 mg sulbactam), given via IV infusion in equally divided doses every 6 hr. ≥40 kg: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) IM/IV every 6 hr. Max treatment duration: 14 days.
Renal impairment: Dose reduction is required.
Intravenous
Intra-abdominal infections
Adult: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) every 6 hr. Max: 4 g sulbactam/day.
Child: ≥1 yr: 300 mg/kg daily (200 mg ampicillin/100 mg sulbactam), given via IV infusion in equally divided doses every 6 hr. ≥40 kg: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) IM/IV every 6 hr. Max treatment duration: 14 days.
Renal impairment: Dose reduction is required.
Intravenous
Skin and skin structure infections
Adult: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) every 6 hr. Max: 4 g sulbactam/day.
Child: ≥1 yr: 300 mg/kg daily (200 mg ampicillin/100 mg sulbactam), given via IV infusion in equally divided doses every 6 hr. ≥40 kg: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) IM/IV every 6 hr. Max treatment duration: 14 days.
Renal impairment: Dose reduction is required.
Intravenous
Acute pelvic inflammatory disease
Adult: 3 g (2 g ampicillin/1 g sulbactam) every 6 hr with doxycycline. Discontinue IV therapy 24 hr after clinical improvement; continue with oral doxycycline (100 mg bid) for 14 days to complete treatment.
Renal impairment: Dose reduction is required.

Special Populations: Dose and/or frequency of drug may need to be modified in renal impairment, but the ratio of ampicillin to sulbactam should still be kept at 2:1.
Contraindications
Hypersensitivity.
Warnings / Precautions
Hepatic disease, biliary obstruction, ingestion of alcohol, pregnancy and lactation.
Adverse Reactions
GI disturbances; hypersensitivity.
Potentially Fatal: Stevens-Johnson syndrome.
Drug Interactions
Probenecid may increase the serum concentrations of sulbactam.
See Below for More sulbactam Drug Interactions
Mechanism of Actions
Sulbactam, a penicillanic acid sulfone with β-lactamase inhibitory properties has weak antibacterial activity, but is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases. It has a similar spectrum of β-lactamase inhibition to clavulanic acid, although it is less potent. It enhances the activity of penicillins and cephalosporins. It is usually given with ampicillin to increase the antimicrobial spectrum; may also be used with cefoperazone.
Absorption: Poorly absorbed from the GI tract.
Distribution: Distributed into breast milk. Protein binding: 38%.
Excretion: Half-life elimination: 1-1.3 hr. About 75-85% is excreted unchanged in the urine within 8 hr.
Storage Conditions
Intravenous: Sterile powder for inj: Store below 20°C.
ATC Classification
J01CG01 - sulbactam ; Belongs to the class of beta-lactamase inhibitors. Used in the systemic treatment of infections.
Storage
Intravenous: Sterile powder for inj: Store below 20°C.
Available As
  • Sulbactam 0.5 gm
  • Sulbactam 1 mg
  • Sulbactam Sodium 1000 mg
  • Sulbactam 1000 mg
  • Sulbactam 125 mg
  • Sterile Sulbactam 125 mg
  • Sulbactam Sodium 125 mg
  • Sulbactam 147 mg
  • Sulbactam 150 mg
  • Sulbactam 2 mg
  • Sulbactam Sodium 250 mg
  • Sulbactam 250 mg
  • Sulbactam Sodium 500 mg
  • Sterile Sulbactam 500 mg
  • Sulbactam 500 mg
  • Sulbactam 62.5 mg
  • Sulbactam 750 mg
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