Indications |
Intravenous Gynaecological infections Adult: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) every 6 hr. Max: 4 g sulbactam/day. Child: ≥1 yr: 300 mg/kg daily (200 mg ampicillin/100 mg sulbactam), given via IV infusion in equally divided doses every 6 hr. ≥40 kg: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) IM/IV every 6 hr. Max treatment duration: 14 days. Renal impairment: Dose reduction is required. Intravenous Intra-abdominal infections Adult: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) every 6 hr. Max: 4 g sulbactam/day. Child: ≥1 yr: 300 mg/kg daily (200 mg ampicillin/100 mg sulbactam), given via IV infusion in equally divided doses every 6 hr. ≥40 kg: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) IM/IV every 6 hr. Max treatment duration: 14 days. Renal impairment: Dose reduction is required. Intravenous Skin and skin structure infections Adult: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) every 6 hr. Max: 4 g sulbactam/day. Child: ≥1 yr: 300 mg/kg daily (200 mg ampicillin/100 mg sulbactam), given via IV infusion in equally divided doses every 6 hr. ≥40 kg: 1.5 g (1 g ampicillin/0.5 g sulbactam) -3 g (2 g ampicillin/1 g sulbactam) IM/IV every 6 hr. Max treatment duration: 14 days. Renal impairment: Dose reduction is required. Intravenous Acute pelvic inflammatory disease Adult: 3 g (2 g ampicillin/1 g sulbactam) every 6 hr with doxycycline. Discontinue IV therapy 24 hr after clinical improvement; continue with oral doxycycline (100 mg bid) for 14 days to complete treatment. Renal impairment: Dose reduction is required. Special Populations: Dose and/or frequency of drug may need to be modified in renal impairment, but the ratio of ampicillin to sulbactam should still be kept at 2:1. |
Contraindications |
Hypersensitivity. |
Warnings / Precautions |
Hepatic disease, biliary obstruction, ingestion of alcohol, pregnancy and lactation. |
Adverse Reactions |
GI disturbances; hypersensitivity. Potentially Fatal: Stevens-Johnson syndrome. |
Drug Interactions |
Probenecid may increase the serum concentrations of sulbactam. See Below for More sulbactam Drug Interactions |
Mechanism of Actions |
Sulbactam, a penicillanic acid sulfone with β-lactamase inhibitory properties has weak antibacterial activity, but is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases. It has a similar spectrum of β-lactamase inhibition to clavulanic acid, although it is less potent. It enhances the activity of penicillins and cephalosporins. It is usually given with ampicillin to increase the antimicrobial spectrum; may also be used with cefoperazone. Absorption: Poorly absorbed from the GI tract. Distribution: Distributed into breast milk. Protein binding: 38%. Excretion: Half-life elimination: 1-1.3 hr. About 75-85% is excreted unchanged in the urine within 8 hr. |
Storage Conditions |
Intravenous: Sterile powder for inj: Store below 20°C. |
ATC Classification |
J01CG01 - sulbactam ; Belongs to the class of beta-lactamase inhibitors. Used in the systemic treatment of infections. |
Storage |
Intravenous: Sterile powder for inj: Store below 20°C. |
Available As |
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Sulbactam
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Sulbactam Containing Brands
Sulbactam is used in following diseases
Drug - Drug Interactions of Sulbactam
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