Stanozolol

Indications
 Oral
Vascular manifestations of Behcet's syndrome
Adult: 10 mg daily.
Oral
Hereditary angioedema
Adult: Initially, 2.5-10 mg daily, reduced according to response. Maintenance: 2 mg daily or on alternate days or 2.5 mg 3 times wkly.
Child: <6 yr: 1 mg daily; 6-12 yr: Up to 2 mg daily.
Intramuscular
Osteopetrosis
Adult: 50 mg every 2-3 wk.
Intramuscular
Anaemia
Adult: 50 mg every 2-3 wk.
Intramuscular
Breast cancer in postmenopausal women
Adult: 50 mg every 2-3 wk.
Intramuscular
Catabolic disorders
Adult: 50 mg every 2-3 wk.
Contraindications
 Pregnancy and lactation; carcinoma of prostate or breast in men, hypercalcaemia, hypercalciuria, porphyria, severe hepatic impairment.
Warnings / Precautions
 Patients with cardiac, renal or hepatic disease, epilepsy or DM. Children, elderly. Monitor liver function, haematocrit and haemoglobin concentrations. Not recommended for treatment of hereditary angioedema in premenopausal women.
Adverse Reactions
 Peliosis hepatis, premature epiphyseal closure, cholestatic jaundice, virilism, impotence, priapism, testicular atrophy, gynaecomastia, prostatic hyperplasia, decreased libido, hirsutism, menstrual irregularities; oedema, acne.
Potentially Fatal: Hepatic necrosis, hepatocellular carcinoma.
Drug Interactions
 Enhances activity of insulin, sulfonylureas, levothyroxine and anticoagulants e.g. warfarin. May cause resistance to the effects of neuromuscular blockers.
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Lab Interactions
 May interfere with laboratory tests for glucose tolerance and thyroid function.
Mechanism of Actions
 Stanozolol is a structural analogue of testosterone which increases collagen production and decreases the anti-anabolic action of cortisone. It is also reported to reduce fibrin deposition. It corrects the formation of kinin or kinin-like factors which may be associated with oedema and swelling seen in hereditary angioedema.
Metabolism: Hepatic.
Excretion: Urine (90%), faeces (6%).
ATC Classification
 A14AA02 - stanozolol ; Belongs to the class of androstan derivative anabolic steroids used as systemic anabolic agents.
Available As
  • Stanozolol 2 mg

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