Sodium Acetate

Indications
 Intravenous
As a source of sodium
Adult: May be added to large volume IV fluids to prevent or correct hyponatraemia in patients with restricted or no oral intake. Dose and rate of administration depends on the needs of the patient. Monitor serum sodium for dosage adjustments.
Elderly: Lower doses may be required.
Contraindications
 Respiratory or metabolic alkalosis, hypocalcaemia, hyponatraemia, fluid retention.
Warnings / Precautions
 Renal failure, severe renal insufficiency and in clinical states where there is oedema with sodium retention, hepatic failure, heart failure, hypertension, eclampsia, aldosteronism. Avoid extravasation. Pregnancy.
Adverse Reactions
 Thrombosis, hypervolaemia; chemical cellulitis at inj site (extravasation); hypernatraemia, dilution of serum electrolytes, over-hydration, hypokalaemia, metabolic alkalosis, hypocalcaemia; gastric distension, flatulence; phlebitis; pulmonary oedema; congestive conditions.
Overdose Reactions
 Discontinue treatment and initiate corrective measures to reduce increased sodium levels and restore acid-base balance.
Drug Interactions
 May affect the absorption of certain drugs due to increased intra-gastric pH. May increase renal clearance of acidic drugs e.g. salicylates and barbiturates, and prolongs the half-life of basic drugs.
See Below for More sodium acetate Drug Interactions
Mechanism of Actions
 Sodium plays an important role in controlling the total body water and its distribution. Sodium is the main cation in the extracellular fluid and comprises >90% of total cations. The acetate component is an alternate source of bicarbonate by metabolic conversion in the liver.
Metabolism: Occurs rapidly and completely into bicarbonate even in the presence of severe liver disease.
Storage Conditions
 Intravenous: Store at 20-25°C.
ATC Classification
 B05XA08 - sodium acetate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
Storage
 Intravenous: Store at 20-25°C.
Available As
  • Sodium Acetate 0.28 gm
  • Sodium Acetate 0.315 gm
  • Sodium Acetate 0.33 gm
  • Sodium Acetate 0.39%
  • Sodium Acetate 0.39% w/v
  • Sodium Acetate 0.390% w/v
  • Sodium Acetate 0.390% w/w
  • Sodium Acetate 0.390%w/v
  • Sodium Acetate 0.64 gm
  • Sodium Acetate 100 mg
  • Sodium Acetate 116 mg
  • Sodium Acetate 125 mg
  • Sodium Acetate 142 mg
  • Sodium Acetate 205 mg
  • Sodium Acetate 275 mg
  • Sodium Acetate 310 mg
  • Sodium Acetate 320 mg
  • Sodium Acetate 373.33 mg
  • Sodium Acetate 500 mg

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