Sitagliptin

Indications
Oral
Type 2 diabetes mellitus
Adult: 100 mg once daily.
CrCl (ml/min)Dosage Recommendation
30-<5050 mg daily.
<30 25 mg daily; may be given without regard to the timing of the haemodialysis.
Contraindications
Type 1 diabetes. Diabetic ketoacidosis.
Warnings / Precautions
Discontinue treatment if there are signs of hypersensitivity. Caution when used with sulphonylureas and/or other antidiabetic medications; monitor blood glucose regularly. Renal impairment; dose adjustment may be needed. Children <18 yr. Pregnancy, lactation.
Adverse Reactions
Headache, diarrhoea, upper respiratory tract infection, nasopharyngitis. Angioedema, exfoliative dermatitis, hypoglycaemia.
Potentially Fatal: Anaphylaxis and/or severe dermatologic reactions such as Stevens-Johnson syndrome.
Overdose Reactions
Treatment: Supportive measures; remove unabsorbed material from the GI tract, clinical monitoring and institute supportive therapy as needed.
Drug Interactions
Concurrent use may increase serum levels of digoxin. Increased risk of hypoglycaemia when used with sulphonylureas.
See Below for More sitagliptin Drug Interactions
Mechanism of Actions
Sitagliptin inhibits dipeptidyl peptidase IV (DPP-IV), resulting in prolonged active incretin levels. Incretin hormones increases insulin synthesis and release from pancreatic β-cells and reduces glucagon secretion from pancreatic α-cells. Reduced glucagon secretion leads to decreased hepatic glucose production.
Absorption: Rapid absorption. Bioavailability: About 87%.
Distribution: Protein binding: 38%.
Metabolism: Not extensively metabolised.
Excretion: Elimination half-life: 12 hr. 87% excreted in urine (mainly as unchanged drug) and 13% excreted in faeces.
Administration
May be taken with or without food.
Storage Conditions
Oral: Store at 20-25°C.
ATC Classification
A10BH01 - sitagliptin ; Belongs to the class of dipeptidyl peptidase 4 (DPP-4) inhibitors. Used in the treatment of diabetes.
Storage
Oral: Store at 20-25°C.
Available As
  • Sitagliptin 100 mg
  • Sitagliptin 25 mg
  • Sitagliptin 50 mg
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    One Response to Sitagliptin

    1. PM Rajendran May 19, 2013 at 9:41 am #

      In the above page Sitagpliptin indication, dose , you have mentioned about Cr/Cl ml/min. What does it mean for a diabetic patient. How it is tested. What is the important of this value. Can you elaborate.
      Regards
      P.M. Rajendran

    Post Review about Sitagliptin

     


    Sitagliptin Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Janumet (50+1000)
    Merck Sharp & Dohme (MSD) 1 Tablet
    ₹ 22.00
    14 Tablet
    ₹ 308.00
  • More Information Metformin 1000 mg
  • More Information Sitagliptin 50 mg
  • See Brands having above combination
    Tablet Janumet (50+500)
    Merck Sharp & Dohme (MSD) 1 Tablet
    ₹ 30.80
    10 Tablet
    ₹ 308.00
  • More Information Metformin 500 mg
  • More Information Sitagliptin 50 mg
  • See Brands having above combination
    Tablet Januvia (100 mg)
    Merck Sharp & Dohme (MSD) 1 Tablet
    ₹ 42.71
    7 Tablet
    ₹ 299.00
  • More Information Sitagliptin 100 mg
  • See Brands having above combination
    Tablet Januvia (25 mg)
    Merck Sharp & Dohme (MSD) 1 Tablet
    ₹ 42.71
    7 Tablet
    ₹ 299.00
  • More Information Sitagliptin 25 mg
  • See Brands having above combination
    Tablet Januvia (50 mg)
    Merck Sharp & Dohme (MSD) 1 Tablet
    ₹ 42.71
    7 Tablet
    ₹ 299.00
  • More Information Sitagliptin 50 mg
  • See Brands having above combination
    Tablet Istamet (50+1000)
    Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 22.00
    14 Tablet
    ₹ 308.00
  • More Information Metformin 1000 mg
  • More Information Sitagliptin 50 mg
  • See Brands having above combination
    Tablet Istamet (50+500)
    Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 22.00
    14 Tablet
    ₹ 308.00
  • More Information Metformin 500 mg
  • More Information Sitagliptin 50 mg
  • See Brands having above combination
    Tablet Istavel (100 mg)
    Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 42.71
    7 Tablet
    ₹ 299.00
  • More Information Sitagliptin 100 mg
  • See Brands having above combination
    Tablet Istavel (25 mg)
    Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 42.71
    7 Tablet
    ₹ 299.00
  • More Information Sitagliptin 25 mg
  • See Brands having above combination
    Tablet Istavel (50 mg)
    Sun Pharmaceutical Industries Ltd. 1 Tablet
    ₹ 29.90
    10 Tablet
    ₹ 299.00
  • More Information Sitagliptin 50 mg
  • See Brands having above combination
    Sitagliptin is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Sitagliptin
    Interaction
    Minor, Monitor Therapy Digoxin vs SitaGLIPtin
    Minor, Monitor Therapy Sitagliptin vs Thiazide Diuretics
    Moderate, Consider therapy modification Sitagliptin vs Somatropin
    Minor, Monitor Therapy Sitagliptin vs P-glycoprotein/ABCB1 Inhibitors
    Minor, Monitor Therapy Sitagliptin vs P-glycoprotein/ABCB1 Inducers
    Minor, Monitor Therapy Sitagliptin vs Pegvisomant
    Minor, Monitor Therapy Sitagliptin vs Luteinizing Hormone-Releasing Hormone Analogs
    Minor, Monitor Therapy Sitagliptin vs Hypoglycemic Agents
    Minor, Monitor Therapy Sitagliptin vs Herbs (Hypoglycemic Properties)
    Minor, Monitor Therapy Sitagliptin vs Digoxin
    Pages: 1 2 3 Next