Silver Sulphadiazine

Indications
 Topical/Cutaneous
Treatment and prophylaxis of infection in severe burns
Adult: Apply a 1% cream onto affected area once or twice daily.
Contraindications
 Hypersensitivity to sulphonamides; porphyria; premature infants and infants <2 mth; pregnancy and lactation.
Warnings / Precautions
 Impaired hepatic or renal function; G6PD deficiency; maintain adequate fluid intake. Monitor blood counts. Systemic absorption, resulting in argyria may occur if it is applied to large wound areas and over prolonged periods.
Adverse Reactions
 Nausea, vomiting, diarrhoea; hypersensitivity, skin reactions; haematuria; crystalluria; thrombocytopenia, leucopenia, eosinophilia.
Potentially Fatal: Stevens-Johnson syndrome; agranulocytosis, jaundice, hepatitis.
Drug Interactions
 Potentiates antidiabetic effect of sulphonylureas. Not antagonised by PABA.
See Below for More silver sulfadiazine Drug Interactions
Mechanism of Actions
 Silver sulfadiazine has broad antimicrobial activity; it is active against gram-positive and gram-negative bacteria as well as some yeasts and fungi. The silver salt acts mainly on the cell wall and membrane to disrupt its intergrity thus allowing it to impair the essential enzymes, bacterial DNA and RNA leading to cell death.
Absorption: Slowly releases sulfadiazine when it comes into contact with wound exudates. Up to 10% of sulfadiazine may be absorbed.
ATC Classification
 D06BA01 - silver sulfadiazine ; Belongs to the class of topical sulfonamides used in the treatment of dermatological diseases.
Available As
  • Silver Sulphadiazine 1%
  • Silver Sulphadiazine 1% v/v
  • Silver Sulphadiazine 1% w/v
  • Silver Sulphadiazine 1% w/w
  • Silver Sulphadiazine 1.0%
  • Silver Sulphadiazine 1.00% w/w

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    Silver Sulphadiazine is used in following diseases

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