Indications |
Oral Severe invasive amoebiasis Adult: 1.5 g daily as single or in divided doses for 5 days. Child: 30 mg/kg daily for 5 days. Oral Trichomoniasis Adult: 2 g as a single dose. Child: 30 mg/kg as a single dose. Oral Amoebiasis Adult: 2 g as a single dose. Child: 30 mg/kg as a single dose. Oral Giardiasis Adult: 2 g as a single dose. Child: 30 mg/kg as a single dose. |
Contraindications |
Hypersensitivity; pregnancy (1st trimester) and lactation. |
Warnings / Precautions |
Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders. |
Adverse Reactions |
Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances. |
Drug Interactions |
Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life. Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage. See Below for More secnidazole Drug Interactions |
Mechanism of Actions |
Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage. |
ATC Classification |
P01AB07 - secnidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases. |
Available As |
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Secnidazole
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Secnidazole Containing Brands
Secnidazole is used in following diseases
Drug - Drug Interactions of Secnidazole
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