Roxithromycin

Indications
Oral
Susceptible infections
Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections.
Child: 6-40 kg: 5-8 mg/kg daily.
Renal impairment: Dosage adjustment may be required.
Hepatic impairment: Usual daily doses should be halved in hepatic impairment.

Special Populations: Cirrhosis: 150 mg once daily.
Contraindications
Hypersensitivity. Porphyria.
Warnings / Precautions
Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.
Adverse Reactions
Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.
Drug Interactions
May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.
See Below for More roxithromycin Drug Interactions
Mechanism of Actions
Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Absorption: Plasma concentrations peak after 2 hr (oral); reduced if taken after food. Bioavailability: about 50%.
Distribution: Widely distributed into body tissues and fluids. Protein-binding: 96% at trough concentrations.
Metabolism: Small amounts are metabolised in the liver.
Excretion: Mainly via the faeces as unchanged drug and metabolites, via the urine (7-12%) and the lungs (15%). Elimination half-life: 8-13 hr. May be prolonged in renal and hepatic impairment, children.
Administration
Should be taken on an empty stomach. (Take before meals.)
ATC Classification
J01FA06 - roxithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Available As
  • Roxithromycin 150 mg
  • Roxithromycin 25 mg
  • Roxithromycin 300 mg
  • Roxithromycin 50 mg
  • Roxithromycin 500 mg
  • Roxithromycin 75 mg
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    Roxithromycin Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Q Rox Kid (50 mg) Que Pharma Pvt.Ltd 1 Tablet
    ₹ 1.50
    10 Tablet
    ₹ 15.00
  • More Information Roxithromycin 50 mg
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    Tablet Roxypen (150 mg) Morepen Laboratories Ltd. 1 Tablet
    ₹ 1.96
    10 Tablet
    ₹ 19.60
  • More Information Roxithromycin 150 mg
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    Tablet Roxypen DT (50 mg) Morepen Laboratories Ltd. 1 Tablet
    ₹ 0.92
    10 Tablet
    ₹ 9.20
  • More Information Roxithromycin 50 mg
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    Suspension Roxson (30 ml) Redson Pharmaceuticals 1 ml
    ₹ 0.97
    30 ml
    ₹ 29.20
  • More Information Roxithromycin 50 mg
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    Tablet Roxithromycin (50 mg) Cyper Pharma 1 Tablet
    ₹ 2.96
    10 Tablet
    ₹ 29.60
  • More Information Roxithromycin 50 mg
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    Suspension Roxina (30 ml) Hamax Pharmaceuticals 1 ml
    ₹ 1.20
    30 ml
    ₹ 36.00
  • More Information Roxithromycin 50 mg
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    Tablet Roxinga (50 mg) Inga Laboratories Pvt. Ltd. 1 Tablet
    ₹ 1.97
    10 Tablet
    ₹ 19.65
  • More Information Roxithromycin 50 mg
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    Tablet Roxalgo (150 mg) Terrace Pharmaceuticals (P) Ltd 1 Tablet
    ₹ 1.20
    10 Tablet
    ₹ 12.00
  • More Information Roxithromycin 150 mg
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    Suspension Starox (60 ml) Bhavishya Pharmaceuticals Pvt Ltd 5 ml
    ₹ 1.33
    60 ml
    ₹ 16.00
  • More Information Roxithromycin 150 mg
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    Tablet Vrox (150 mg) Robin Pharmaceuticals 1 Tablet
    ₹ 0.56
    100 Tablet
    ₹ 56.00
  • More Information Roxithromycin 150 mg
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