Risperidone

Indications
Oral
Schizophrenia
Adult: Initially, 2 mg daily, may increase to 4 mg daily on the 2nd day, adjusted further in increments or decrements of 1-2 mg daily at wkly intervals. Doses may be given in 1-2 divided doses. Maintenance: 4-6 mg daily. Max: 16 mg/day.
Elderly: Initially, 0.5 mg bid gradually increased in increments of 0.5 mg bid. Maintenance: 1-2 mg bid.
Renal impairment: Initially, 0.5 mg bid, may increase in steps of 0.5 mg bid, up to 1-2 mg bid. Dose increments above 1.5 mg bid should be made at intervals of at least 1 wk.
Hepatic impairment: Initially, 0.5 mg bid, may increase in steps of 0.5 mg bid, up to 1-2 mg bid. Dose increments above 1.5 mg bid should be made at intervals of at least 1 wk.
Oral
Acute manic episodes of bipolar disorder
Adult: Initially, 2-3 mg once daily. May increase by 1 mg daily at intervals of at least 24 hr. Max: 6 mg daily.
Elderly: Initiate with lower doses.
Renal impairment: Initially, 0.5 mg bid, may increase in steps of 0.5 mg bid, up to 1-2 mg bid. Dose increments above 1.5 mg bid should be made at intervals of at least 1 wk.
Hepatic impairment: Initially, 0.5 mg bid, may increase in steps of 0.5 mg bid, up to 1-2 mg bid. Dose increments above 1.5 mg bid should be made at intervals of at least 1 wk.
Intramuscular
Schizophrenia
Adult: Give oral risperidone for a few days to assess tolerability prior to initiating inj. For patients not stabilised on oral risperidone: 25 mg every 2 wk. Patients stabilised on oral risperidone for at least 2 wk in doses ≤4 mg daily: 25 mg every 2 wk. Patients stabilised on oral risperidone for at least 2 wk in doses >4 mg daily: 37.5 mg every 2 wk. Continue oral risperidone for the 1st 3 wk after the 1st inj.
Elderly: Max dose: 25 mg every 2 wk.

Special Populations: Patients with hepatic or renal impairment: 0.5 mg bid, increased to 1-2 mg bid.
Warnings / Precautions
Preexisting CV diseases; discontinue use if signs and symptoms of tardive dyskinesia occur; renal and hepatic impairment, elderly, epilepsy; parkinsonism; pregnancy. May cause drowsiness and orthostatic hypotension. Gradual withdrawal is recommended. Monitor blood glucose in diabetics and patients at risk of developing diabetes.
Adverse Reactions
Agitation, anxiety, dizziness, headache, somnolence; orthostatic hypotension; constipation, dyspepsia, nausea, vomiting, abdominal pain, blurred vision, erectile dysfunction, priapism, rhinitis, rash and allergy, galactorrhoea, gynaecomastia, menstrual disorders, extrapyramidal symptoms (rarely). weight gain, oedema, tardive dyskinesia.
Potentially Fatal: Neuroleptic malignant syndrome may occur rarely; seizures. May cause increased mortality in elderly with dementia-related psychosis.
Overdose Reactions
May lead to tachycardia, hypotension and extrapyramidal symptoms. In cases of acute overdosage, maintain airway and ensure sufficient oxygenation and ventilation. Gastric lavage and admin of activated charcoal with a laxative may be considered. Monitor ECG and CV status.
Drug Interactions
May antagonise the effects of levodopa and dopamine agonists. May increase serum levels of clozapine when used together. Increased serum levels of carbamazepine when used concurrently. Carbamazepine may also decrease the serum levels of risperidone. Increased risk of neuroleptic malignant syndrome when used with indinavir and ritonavir.
Potentially Fatal: Risperidone may enhance the hypotensive effect of certain antihypertensives.
See Below for More risperidone Drug Interactions
Mechanism of Actions
Risperidone is an atypical antipsychotic. Its activity is mediated through a combination of dopamine (D2) and serotonin (5-HT2) receptor antagonism. It also exhibits affinity to adrenergic (α1 and α2) and histamine (H1) receptors. It is less likely to cause extrapyramidal effects than conventional antipsychotics.
Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr.
Distribution: Protein-binding: 90% (risperidone), 70% (9-hydroxyrisperidone).
Metabolism: Extensively hepatic by hydroxylation.
Excretion: Mainly in the urine and, to a lesser extent in the faeces.
Administration
May be taken with or without food.
Storage Conditions
Oral: Store at 15-25°C.
ATC Classification
N05AX08 - risperidone ; Belongs to the class of other antipsychotics.
Storage
Oral: Store at 15-25°C.
Available As
  • Risperidone 0.5 mg
  • Risperidone 1 mg
  • Risperidone 10 mg
  • Risperidone 2 mg
  • Risperidone 2.0 mg
  • Risperidone 3 mg
  • Risperidone 4 mg
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    Risperidone Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Psydon (1 mg) Psyco Remedies. 1 Tablet
    ₹ 0.97
    10 Tablet
    ₹ 9.70
  • More Information Risperidone 1 mg
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    Tablet Rasin (1 mg) Pifer Pharmaceuticals Pvt Ltd 1 Tablet
    ₹ 0.90
    10 Tablet
    ₹ 9.00
  • More Information Risperidone 1 mg
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    Tablet R Don (1 mg) Elite Pharma Pvt Ltd 1 Tablet
    ₹ 0.90
    10 Tablet
    ₹ 9.00
  • More Information Risperidone 1 mg
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    Tablet Riposh (1 mg) Osho Pharma Pvt.Ltd. 1 Tablet
    ₹ 0.90
    10 Tablet
    ₹ 9.00
  • More Information Risperidone 1 mg
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    Tablet Rion (1 mg) Zee Laboratories Ltd 1 Tablet
    ₹ 0.90
    10 Tablet
    ₹ 9.00
  • More Information Risperidone 1 mg
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    Tablet Respimed (1 mg) Medico Labs. 1 Tablet
    ₹ 0.80
    10 Tablet
    ₹ 8.00
  • More Information Risperidone 1 mg
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    Tablet Repid (1 mg) Tas Med (I) Pvt. Ltd. 1 Tablet
    ₹ 0.90
    10 Tablet
    ₹ 9.00
  • More Information Risperidone 1 mg
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    Tablet Risnia (1 mg) Protec (Cipla Ltd) 1 Tablet
    ₹ 0.94
    10 Tablet
    ₹ 9.36
  • More Information Risperidone 1 mg
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    Tablet Rispid (1 mg) Ecolity (Panacea Biotec Ltd.) 1 Tablet
    ₹ 0.74
    10 Tablet
    ₹ 7.40
  • More Information Risperidone 1 mg
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    Tablet Ristab (1 mg) Medo Pharma 1 Tablet
    ₹ 0.77
    10 Tablet
    ₹ 7.70
  • More Information Risperidone 1 mg
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    Risperidone is used in following diseases

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    Drug - Drug Interactions of Risperidone
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    Minor, Monitor Therapy Risperidone vs CYP2D6 Inhibitors (Moderate)
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    Minor, Monitor Therapy Risperidone vs CNS Depressants
    Minor, Monitor Therapy Risperidone vs Ciprofloxacin (Systemic)
    Pages: 1 2 3 4 5 6 7 Next