Reboxetine

Indications
Oral
Depression
Adult: 4 mg bid, may increase to 10 mg daily after 3-4 wk if necessary. Max: 12 mg daily.
Elderly: 2 mg bid, may increase dose to 6 mg/day after 3 ww if required.
Renal impairment: Initiate with lower doses: 2 mg bid; may increase gradually according to tolerance.
Hepatic impairment: Initiate with lower doses: 2 mg bid; may increase gradually according to tolerance.

Special Populations: Reduce initial dose to 4 mg daily in patients with hepatic or renal impairment.
Warnings / Precautions
Renal and hepatic impairment, benign prostatic hyperplasia, cardiac disorders, epilepsy, bipolar disorders, urinary retention, glaucoma. May impair ability to perform tasks requiring mental alertness, driving or operating machinery. Monitor for signs of clinical worsening eg. suicidal tendency especially during the initial phase of the treatment.
Adverse Reactions
Insomnia, dizziness, increased sweating, impotence, dry mouth, constipation, urinary hesitancy, dry mouth, postural hypotension, dysuria, paraesthesia, hyponatraemia, tachycardia.
Potentially Fatal: Tachycardia.
Drug Interactions
Avoid concomitant admin with antiarrhythmics, antipsychotics, ciclosporin, imidazole and triazole antifungals, TCAs. Concurrent use with CYP3A4 inhibitors may increase plasma levels of reboxetine. Concurrent use with ergot derivatives may increase BP.
Potentially Fatal: Risk of hypertensive crisis when used with MAOIs.
See Below for More reboxetine Drug Interactions
Mechanism of Actions
Reboxetine selectively and potently inhibits norepinephrine reuptake. It also has a weak effect on serotonin reuptake.
Absorption: Well absorbed; peak plasma concentrations about 2 hr after oral dose.
Distribution: Protein-binding: 97%.
Metabolism: Metabolised by CYP3A4. Dealkylation, hydroxylation, oxidation followed by glucuronide and sulfate conjugations.
Excretion: Mainly via urine (78%) with 10% as unchanged drug; 13 hr (elimination half-life).
Administration
May be taken with or without food.
ATC Classification
N06AX18 - reboxetine ; Belongs to the class of other antidepressants.
Available As
  • Reboxetine 2 mg
  • Reboxetine 4 mg
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    Reboxetine Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Narebox (2 mg)
    Zydus Neurosciences (Zydus Cadila Healthcare Ltd) 1 Tablet
    ₹ 2.60
    10 Tablet
    ₹ 26.00
  • More Information Reboxetine 2 mg
  • See Brands having above combination
    Tablet Narebox (4 mg)
    Zydus Neurosciences (Zydus Cadila Healthcare Ltd) 1 Tablet
    ₹ 4.16
    10 Tablet
    ₹ 41.64
  • More Information Reboxetine 4 mg
  • See Brands having above combination
    Tablet Rebotin (2 mg)
    Intas Laboratories Pvt Ltd 1 Tablet
    ₹ 1.60
    10 Tablet
    ₹ 16.00
  • More Information Reboxetine 2 mg
  • See Brands having above combination
    Tablet Rebotin (4 mg)
    Intas Laboratories Pvt Ltd 1 Tablet
    ₹ 3.00
    10 Tablet
    ₹ 30.00
  • More Information Reboxetine 4 mg
  • See Brands having above combination
    Tablet Reboxxin (2 mg)
    Merind Ltd (Wockhardt Ltd) 1 Tablet
    ₹ 1.68
    10 Tablet
    ₹ 16.80
  • More Information Reboxetine 2 mg
  • See Brands having above combination
    Tablet Reboxxin (4 mg)
    Merind Ltd (Wockhardt Ltd) 1 Tablet
    ₹ 3.19
    10 Tablet
    ₹ 31.90
  • More Information Reboxetine 4 mg
  • See Brands having above combination
    Tablet Reboot (2 mg)
    Abbott Healthcare Pvt Ltd (AHPL) 1 Tablet
    ₹ 1.60
    10 Tablet
    ₹ 16.00
  • More Information Reboxetine 2 mg
  • See Brands having above combination
    Tablet Reboot (4 mg)
    Abbott Healthcare Pvt Ltd (AHPL) 1 Tablet
    ₹ 3.00
    10 Tablet
    ₹ 30.00
  • More Information Reboxetine 4 mg
  • See Brands having above combination
    Reboxetine is used in following diseases

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