Rabeprazole

Indications
 Oral
Gastro-oesophageal reflux disease
Adult: For erosive oesophagitis: 20 mg once daily in the morning for 4-8 wk. Maintenance: 10-20 mg once daily according to response. For non-erosive oesophagitis: 10 mg once daily for 4 wk, upon symptom resolution, may continue with 10 mg once daily when necessary.
Oral
Hypersecretory conditions
Adult: Initially, 60 mg daily adjusted according to response. Max dose: 120 mg daily.
Oral
Active peptic ulcer disease
Adult: 20 mg daily given for 4-8 wk for duodenal ulcer and 6-12 wk for gastric ulcer.
Oral
H.pylori infection
Adult: As a combination with two antibacterials: 20 mg bid combined with clarithromycin 500 mg bid and either amoxicillin 1 g bid or metronidazole 400 mg bid. To be taken for a wk.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Severe hepatic impairment, gastric malignancy. May increase the risk of GI infections due to acid suppressive effects. Pregnancy.
Adverse Reactions
 Headache, diarrhoea, rash, infection and flu-like syndrome. Dizziness, fatigue, constipation, nausea and vomiting.
Potentially Fatal: Anaphylaxis, agranulocytosis.
Overdose Reactions
 May result in drowsiness, headache and tachycardia.
Drug Interactions
 May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin and warfarin.
See Below for More rabeprazole Drug Interactions
Food Interactions
 Delayed absorption with high-fat meals.
Mechanism of Actions
 Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell.
Onset: 1 hr.
Duration: 24 hr.
Absorption: Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral admin.
Distribution: Protein-binding: 97%.
Metabolism: Extensively metabolised in the liver by cytochrome P450 isoenzymes.
Excretion: Metabolites are mainly excreted in the urine (90%). Half-life: about 1 hr.
Administration
 Delayed-release: May be taken with or without food.
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 A02BC04 - rabeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Storage
 Oral: Store at 15-30°C.
Available As
  • Rabeprazole 10 mg
  • Rabeprazole Sodium 10 mg
  • Rabeprazole Sodium 20 mg
  • Rabeprazole 20 mg
  • Rabeprazole 30 mg
  • Rabeprazole 40 mg
  • Rabeprazole Sodium 40 mg
  • Rabeprazole 5 mg
  • Rabeprazole Sodium 5 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Rabeprazole


    Rabeprazole Containing Brands

    We are Developing Our database, More results coming soon.

    Rabeprazole is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Rabeprazole

    We are Developing Our database, More results coming soon.