Prulifoxacin

Indications
 Oral
Uncomplicated lower urinary tract infections
Adult: In acute cases (simple cystits): Single dose of 600 mg.
Renal impairment: Dose adjustment is required.
Oral
Acute exacerbations of chronic bronchitis
Adult: 600 mg daily up to 10 days.
Renal impairment: Dose adjustment is required.
Oral
Complicated lower urinary tract infections
Adult: 600 mg daily up to 10 days.
Renal impairment: Dose adjustment is required.
Contraindications
 Hypersensitivity. Pregnancy and lactation. Children or adolescents below 18 yr with uncomplicated skeletal development. History of tendon diseases related to administration of quinolones. Celiac disease.
Warnings / Precautions
 Haemolytic reactions may occur in G6PD deficiency patients. Exposure to sun or UV-ray may cause photosensitivity reactions. Lowers seizure threshold and predisposes CNS disorder patients to convulsions. Caution in patients with hypokalaemia, hypocalcaemia, or in patients who suffer from rhythm disorders. Increased risk of Achilles tendon or other tendon damage especially in elderly patients, concurrent corticosteroids-receiving patients or organ transplant recipients. Crystalluria, rhadomyolysis may occur in rare cases. Prolonged use may result in development of drug-resistant bacteria, or superinfections including Clostridium difficile-associated diarrhoea and pseudomembranous colitis. Renal impairment.
Adverse Reactions
 Nausea, vomiting, epigastric pain, gastritis, diarrhoea, fever, altered taste, cephalalgia, dizziness, drowsiness, sleep disorders, ocular hyperemia, pruritis, skin rash, facial eczema, photosensitivity, muscle spasm, rhabdomyolysis, anorexia.
Potentially Fatal: Hypersensitivity, anaphylactic/anaphylactoid reactions, Stevens-Johnson syndrome.
Drug Interactions
 Concurrent use with cimetidine, aluminium- and magnesium-containing antacids, or preparations containing iron and calcium reduces the absorption of Prulifloxacin. Increased concentration with probenecid. Prulifloxacin may increase serum concentration of theophylline. Quinolones may enhance hypoglycaemic effect of hypoglycaemic agents. May enhance effect of oral anticoagulants such as warfarin and its derivatives. Concurrent use of NSAIDS may increase risk of convulsions.
See Below for More prulifloxacin Drug Interactions
Lab Interactions
 Ingestion of food delays and reduces peak levels. Serum concentration decreases when taken with milk.
Mechanism of Actions
 Prulifloxacin is the prodrug of ulifloxacin. It prevents reproduction of bacterial DNA by inhibiting DNA-gyrase in susceptible organisms.
Absorption: Peak plasma concentration of Ulifloxacin was reached at 1 hr after oral administration.
Distribution: Apparent Vd: 1231 L after a single dose of prulifloxacin 600 mg. About 45% of Ulifloxacin is protein bound.
Metabolism: Extensive 1st pass metabolism to form the active metabolite, Ulifloxacin.
Excretion: Elimination half-life of Ulifloxacin: 10.6-12.1 hr. Ulifloxacin is primarily excreted unchanged by renal clearance.
ATC Classification
 J01MA17 - prulifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Available As
  • Prulifoxacin 500 mg
  • Prulifoxacin 600 mg

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