Prochlorperazine

Indications
 Oral
Prophylaxis of nausea and vomitting
Adult: As maleate or mesilate: 5-10 mg bid/tid. May also be given rectally.
Oral
Nausea and vomiting
Adult: As maleate or mesilate: 20 mg, further doses are given if needed. Recommended buccal dose: As maleate: 3-6 mg bid.
Oral
Psychoses
Adult: As maleate or mesilate: 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily.
Child: 1-5 yr: 1.25-2.5 mg; 5-12 yr: 2.5-5 mg. May be given up to tid, if necessary.
Oral
Adjunct in severe anxiety disorders
Adult: As maleate or mesilate: 5-10 mg, up to 3-4 times daily.
Oral
Vertigo
Adult: As maleate or mesilate: 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended buccal dose: 3-6 mg bid.
Intramuscular
Nausea and vomiting
Adult: As mesilate: 12.5 mg by deep IM. If required, may give further doses via oral admin.
Intramuscular
Psychoses
Adult: As mesilate: 12.5-25 mg by deep IM Inj bid/tid.
Intravenous
Severe nausea and vomiting
Adult: As edisilate: 2.5-10 mg via slow IV inj or infusion at a rate not exceeding 5 mg/minute. Not to exceed 40 mg daily.
Rectal
Nausea and vomiting
Adult: As base: 25 mg bid.
Rectal
Psychoses
Adult: As maleate: 25 mg bid/tid.
Contraindications
 CNS depression, comatose patients. Bone marrow depression, phaechromocytoma, prolactin-dependent tumours, hypersensitivity. Childn <2 yr. Pregnancy and lactation.
Warnings / Precautions
 Extrapyramidal syndrome, hypotension, epilepsy, impaired hepatic, renal, CV, cerebrovascular or respiratory function, glaucoma. May impair ability to drive or perform tasks requiring mental alertness or physical coordination. Parenteral use in children is not recommended. History of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations are recommended in patients on long-term treatment.
Adverse Reactions
 Cholestatic jaundice, cardiac arrhythmias, orthostatic hypotension, leucopaenia, thrombocytopaenia, dry mouth, blurring of vision, glaucoma, urinary retention, constipation, galactorrhoea, gynaecomastia, amenorrhoea and impotence. Buccal: Transient numbness of gum and tongue.
Potentially Fatal: Bone-marrow suppression. Cardiac arrhythmias or aspiration.
Drug Interactions
 Additive anticholinergic effects with antihistamines, tricyclic antidepressants and drugs used in parkinsonism. May reduce the antihypertensive effect of guanethidine and other adrenergic neurone blockers. May also increase risk of arrhythmias when used with drugs that prolong QT interval.
Potentially Fatal: Potentiation of other CNS depressants including alcohol, sedatives, hypnotics, barbiturates, opioids, antihistamines and general anaesthetics.
See Below for More prochlorperazine Drug Interactions
Food Interactions
 None reported.
Mechanism of Actions
 Prochlorperazine blocks both postsynaptic dopamine receptors as well as the medullary chemo receptor trigger zone. It depresses hypothalamic and hypophyseal hormone release and posssesses α-adrenergic and anticholinergic inhibitory activity.
Administration
 May be taken with or without food.
Storage Conditions
 Intramuscular: Store below 30°C. Rectal: Store at 15-30°C.
ATC Classification
 N05AB04 - prochlorperazine ; Belongs to the class of phenothiazine antipsychotics with piperazine structure.
Storage
 Intramuscular: Store below 30°C. Rectal: Store at 15-30°C.
Available As
  • Prochlorperazine 12.5 mg
  • Prochlorperazine Mesylate 12.5 mg
  • Prochlorperazine Maleate 12.5 mg
  • Prochlorperazine Maleate 2.5 mg
  • Prochlorperazine 2.5 mg
  • Prochlorperazine Maleate 25 mg
  • Prochlorperazine 25 mg
  • Prochlorperazine 3 mg
  • Prochlorperazine 5 mg
  • Prochlorperazine Maleate 5 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Prochlorperazine


    Prochlorperazine Containing Brands

    We are Developing Our database, More results coming soon.

    Prochlorperazine is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Prochlorperazine

    We are Developing Our database, More results coming soon.