Piroxicam

Indications
Oral
Rheumatic disorders
Adult: Initially, 20 mg daily as a single dose. Maintenance: 10-30 mg in single or divided doses.
Oral
Acute gout
Adult: 40 mg daily for 5-7 days.
Oral
Acute musculoskeletal disorders
Adult: Initially, 40 mg daily given for 2 days. Maintenance: 20 mg daily for 1-2 wk.
Oral
Postoperative pain
Adult: Initially, 40 mg daily given for 2 days. Maintenance: 20 mg daily for 1-2 wk.
Oral
Juvenile idiopathic arthritis
Child: ≥6 yr: <15 kg: 5 mg, 16-25 kg: 10 mg, 26-45 kg: 15 mg, ≥46 kg: 20 mg. Doses to be taken once daily.
Topical/Cutaneous
Local pain relief
Adult: Apply a 0.5% gel 3-4 times daily over the affected area. Treatment should be reviewed after 4 wk.
Contraindications
Hypersensitivity, active peptic ulceration, porphyria, pregnancy (3rd trimester) and lactation.
Warnings / Precautions
Elderly, childn <12 yr. Patients with infections, asthma, allergic disorders, haemorrhagic disorders or hypertension. Impaired renal, hepatic or cardiac function. Monitor for signs of liver, kidney, blood or eye disorders.
Adverse Reactions
GI disturbances, peptic ulcer, GI bleeding, headache, dizziness, blurred vision, tinnitus, skin rashes and pruritus. Haematological changes and photosensitivity.
Potentially Fatal: Thrombocytopaenia and acute nephropathy. Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Overdose Reactions
Symptoms are usually mild and include nausea and vomiting, headache, drowsiness, blurred vision and dizziness.
Drug Interactions
Increased risk of hyperkalaemia when used with ACE inhibitors and potassium-sparing diuretics. Convulsions may occur when used with quinolones. Effects of phenytoin and sulfonylureas may be enhanced. Antihypertensive effects of ACE inhibitors, β-blockers and diuretics may be reduced. Increased risk of GI bleeding and ulceration when used with corticosteroids, SSRIs or antiplatelet agents. Increased risk of haematotoxicity when used with zidovudine. ACE inhibitors, ciclosporin, tacrolimus or diuretics may increase nephrotoxicity.
Potentially Fatal: May potentiate anticoagulants. Increased levels of lithium, methotrexate and cardiac glycosides.
See Below for More piroxicam Drug Interactions
Lab Interactions
May interfere with thyroid function tests.
Mechanism of Actions
Piroxicam is a NSAID, belonging to the oxicam group. It inhibits prostaglandin synthesis, reduces fever by acting on the heat-regulating center of the hypothalamus, inhibits platelet-aggregating substance thromboxane A2 and reduces pain receptor sensitivity. It also exerts anti-inflammatory effect by lysosomal stabilisation, kinin and leukotriene production, alteration of chemotactic factors and neutrophil activation inhibition.
Absorption: Well absorbed from the GIT (oral); peak plasma concentrations 3-5 hr after an oral dose.
Distribution: Detected in breast milk. Protein-binding: 99%
Metabolism: Hepatic via hydroxylation and conjugation; undergoes enterohepatic recycling.
Excretion: Mainly in urine (as metabolites and unchanged drug), faeces; elimination half-life: 50 hr.
Administration
Should be taken with food.
Storage Conditions
Oral: Store at <30°C. Topical/Cutaneous: Store at <30°C.
ATC Classification
M01AC01 - piroxicam ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, oxicams.
M02AA07 - piroxicam ; Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used in the treatment of joint and muscular pains.
S01BC06 - piroxicam ; Belongs to the class of non-steroidal antiinflammatory agents. Used in the treatment of inflammation of the eye.
Storage
Oral: Store at <30°C. Topical/Cutaneous: Store at <30°C.
Available As
  • Piroxicam 0.5%
  • Piroxicam 0.5% w/w
  • Piroxicam 10 mg
  • Piroxicam 191.2 mg
  • Piroxicam 20 mg
  • Piroxicam 40 mg
  • Piroxicam 48 mg
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    Piroxicam Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Capsule Brexic (10 mg) Wockhardt Ltd. 1 Capsule
    ₹ 1.63
    6 Capsule
    ₹ 9.79
  • More Information Piroxicam 10 mg
  • See Brands having above combination
    Capsule Fedin (20 mg) Synmedic Laboratories 1 Capsule
    ₹ 0.40
    100 Capsul
    ₹ 40.00
  • More Information Piroxicam 20 mg
  • See Brands having above combination
    Tablet Inflavan (10 mg) Khandelwal Laboratories Pvt Ltd. 1 Tablet
    ₹ 0.36
    10 Tablet
    ₹ 3.61
  • More Information Piroxicam 10 mg
  • See Brands having above combination
    Tablet Inflavan (20 mg) Khandelwal Laboratories Pvt Ltd. 1 Tablet
    ₹ 0.46
    10 Tablet
    ₹ 4.61
  • More Information Piroxicam 20 mg
  • See Brands having above combination
    Tablet Kam (20 mg) Dion Pharmaceuticals 1 Tablet
    ₹ 1.20
    100 Tablet
    ₹ 120.00
  • More Information Piroxicam 20 mg
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    Tablet Mepirox (10 mg) Medi Products Pvt.Ltd. 1 Tablet
    ₹ 1.52
    10 Tablet
    ₹ 15.15
  • More Information Piroxicam 10 mg
  • See Brands having above combination
    Capsule Piroxycam (20 mg) Acichem Laboratories 1 Capsule
    ₹ 0.30
    1000 Capsu
    ₹ 300.00
  • More Information Piroxicam 20 mg
  • See Brands having above combination
    Capsule Rocam (20 mg) Aan Pharma Pvt Ltd 1 Capsule
    ₹ 0.90
    10 Capsule
    ₹ 9.00
  • More Information Piroxicam 20 mg
  • See Brands having above combination
    Capsule Zeepain (20 mg) Lark Laboratories (India) Ltd. 1 Capsule
    ₹ 0.89
    10 Capsule
    ₹ 8.93
  • More Information Piroxicam 20 mg
  • See Brands having above combination
    Tablet Zicam DT (20 mg) Terrace Pharmaceuticals (P) Ltd 1 Tablet
    ₹ 0.70
    10 Tablet
    ₹ 7.00
  • More Information Piroxicam 20 mg
  • See Brands having above combination
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    Piroxicam is used in following diseases

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    Drug - Drug Interactions of Piroxicam
    Interaction
    Major, Avoid combination Piroxicam vs Ketorolac (Systemic)
    Major, Avoid combination Piroxicam vs Ketorolac (Nasal)
    Major, Avoid combination Piroxicam vs Ketorolac
    Minor, Monitor Therapy Piroxicam vs Ibritumomab
    Minor, Monitor Therapy Piroxicam vs HydrALAZINE
    Moderate, Consider therapy modification Piroxicam vs Herbs (Anticoagulant/Antiplatelet Properties) (eg, Alfalfa, Anise, Bilberry)
    Moderate, Consider therapy modification Piroxicam vs Herbs (Anticoagulant/Antiplatelet Properties) (eg, Alfalfa, Anise, Bilberry)
    Minor, Monitor Therapy Piroxicam vs Haloperidol
    Minor, Monitor Therapy Piroxicam vs Glucosamine
    Major, Avoid combination Piroxicam vs Floctafenine
    Pages: 1 2 3 4 5 6 Next