Piracetam

Indications
Oral
Adjunct in cortical myoclonus
Adult: 7.2 g daily in 2-3 divided doses, increased by 4.8 g/day every 3-4 days. Max dose: 20 g daily.
CrCl (ml/min)Dosage Recommendation
50-792/3 usual dose
30-491/3 usual dose
20-291/6 usual dose
<20Contra-indicated

Oral
As a cognitive enhancer in cerebrocortical insufficiency
Adult: 2.4 g daily, given as 2-3 divided doses. Up to 4.8 g daily may be used in severe cases.
CrCl (ml/min)Dosage Recommendation
50-792/3 usual dose
30-491/3 usual dose
20-291/6 usual dose
<20Contra-indicated

Parenteral
As a cognitive enhancer in cerebrocortical insufficiency
Adult: 1-2 g tid via IV/IM admin.

Special Populations: Patients with mild to moderate renal impairment: CrCl: 40-60 mL/min: ½ the usual dose; 20-40 mL/min: Quarter of the usual dose.
Contraindications
Hepatic and severe renal impairment. Cerebral haemorrhage. Pregnancy and lactation.
Warnings / Precautions
Avoid abrupt withdrawal. Impaired renal function. Cardiac disorders. Haemostatic disorders. Patients who have recently undergone major surgery. Elderly.
Adverse Reactions
Hyperkinesia, nervousness, depression, diarrhoea, rashes. CNS stimulation, sleep disturbances, dizziness, excitement, insomnia, somnolence, wt gain.
Drug Interactions
May increase prothrombin time in patients who are on warfarin.
See Below for More piracetam Drug Interactions
Mechanism of Actions
Piracetam protects the cerebral cortex against hypoxia. It also inhibits platelet aggregation and reduces blood viscosity.
Administration
Soln: May be taken with or without food. (Take w/ a glass of water or soft drink after taking the undiluted soln to mask bitter taste. )
ATC Classification
N06BX03 - piracetam ; Belongs to the class of other psychostimulants and nootropics.
Available As
  • Piracetam 1 gm
  • Piracetam 100 mg
  • Piracetam 1200 mg
  • Piracetam 200 mg
  • Piracetam 400 mg
  • Piracetam 500 mg
  • Piracetam 800 mg
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